Jatropha curcas hemagglutinin is similar to a 2S albumin allergen from the same source and has unique sugar affinities

CORC > 西双版纳热带植物园 > 中国科学院西双版纳热带植物园 > 热带植物资源可持续利用重点实验室特色文献 > 小桐子相关文献

	Jatropha curcas hemagglutinin is similar to a 2S albumin allergen from the same source and has unique sugar affinities
	Nair, D. N.
刊名	Planta
	2012
卷号	236 期号:5 页码:1499-1505
ISSN号	0032-0935
中文摘要	We have previously reported the purification and preliminary X-ray characterization of a hemagglutinin from the seeds of Jatropha curcas and, with the detailed sequencing information available now, we find that it is similar to a 2S albumin allergen isolated from the same source. Through a search of Jatropha genome database (http://www.kazusa.or.jp/jatropha/), we map it to the sequence id JcCA0234191 (now referred to as Jcr4S00619.70 in the new version, release 4.5) which has a conserved alpha amylase inhibitor/seed storage protein domain found in the 2S albumin allergens. The putative sequence of the small and large chains of the protein is assigned and the total mass of the two subunits matches with the intact mass 10 kDa determined through MALDI. The protein retains hemagglutination activity between pH 6-9 and up to 60 degrees C on heat treatment and its hemagglutination activity is inhibited by sialic acid and fetuin. Bioinformatics studies show that the isolated protein sequence clusters in close association with a 2S albumin from Ricinus communis in phylogeny analysis and has a conservation of the characteristic four disulfide linkage pattern. Hemagglutinins and lectins are known to have allergenic effects through their interaction with immunoglobulin E and histamine release and earlier studies have shown that this interaction can be inhibited by lectin-specific sugars. We hope this report bridges the plant allergens and hemagglutinins further for exploring possible mediation of allergenic activity through sialic acid and complex sugar interactions and generates further interest in the area.
公开日期	2015-01-28
内容类型	期刊论文
源URL	[http://ir.xtbg.org.cn/handle/353005/7894]
专题	西双版纳热带植物园_热带植物资源可持续利用重点实验室特色文献_小桐子相关文献
推荐引用方式 GB/T 7714	Nair, D. N.. Jatropha curcas hemagglutinin is similar to a 2S albumin allergen from the same source and has unique sugar affinities[J]. Planta,2012,236(5):1499-1505.
APA	Nair, D. N..(2012).Jatropha curcas hemagglutinin is similar to a 2S albumin allergen from the same source and has unique sugar affinities.Planta,236(5),1499-1505.
MLA	Nair, D. N.."Jatropha curcas hemagglutinin is similar to a 2S albumin allergen from the same source and has unique sugar affinities".Planta 236.5(2012):1499-1505.