Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof
	Jiang, Shi-Zhi 1,2; Lei, Ting1,2 ; Wei, Kun 1; Yang, Yu-Rong1
刊名	ORGANIC LETTERS
	2014-11-07
卷号	16 期号:21 页码:5612-5615
关键词	ALSTONIA-SCHOLARIS NEUROGENESIS PROLIFERATION
ISSN号	1523-7060
通讯作者	Yang,YR (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; yangyurong@mail.kib.ac.cn
产权排序	第一
英文摘要	The collective total synthesis of tetracyclic diquinane Lycopodium alkaloids, (+)-paniculatine, (-)-magellanine, (+)-magellaninone, and two analogues (-)-13-epi-paniculatine and (+)-3-hydroxyl-13-dehydro-paniculatine, has been accomplished. By logic-guided addition of a strategically useful hydroxyl group at C-3 of paniculatine, the formidable tetracyclic core was rapidly synthesized utilizing a site-specific and stereoselective aldol cyclization, thus making the ABD -> ABCD tetracyclic approach to diquinane Lycopodium alkaloids attainable for the first time.
学科主题	Chemistry, Organic
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	CHIRAL BICYCLIC LACTAMS ; 1ST TOTAL-SYNTHESIS ; ASYMMETRIC-SYNTHESIS ; HELQUIST ANNULATION ; MAGELLANINE-TYPE ; L-PANICULATUM ; (-)-8-DEOXYSERRATININE
收录类别	SCI ; IC
资助信息	National Natural Science Foundation of China [81202436]; National Science Foundation of China for Distinguished Young Scholars [81025023]; Youth Innovation Promotion Association, CAS
语种	英语
WOS记录号	WOS:000344635200027
公开日期	2015-01-20
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18468]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Shi-Zhi,Lei, Ting,Wei, Kun,et al. Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof[J]. ORGANIC LETTERS,2014,16(21):5612-5615.
APA	Jiang, Shi-Zhi,Lei, Ting,Wei, Kun,&Yang, Yu-Rong.(2014).Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof.ORGANIC LETTERS,16(21),5612-5615.
MLA	Jiang, Shi-Zhi,et al."Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof".ORGANIC LETTERS 16.21(2014):5612-5615.