Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 水生生物分子与细胞生物学研究中心 > 期刊论文

	Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer
	Feng, Maohui 1; Fang, Xiping 2; Yang, Qian 1; Ouyang, Gang 3; Chen, Daping 1; Ma, Xiang 1; Li, Huachi 1; Xie, Wei 1
刊名	ONCOLOGY LETTERS
	2014-07-01
卷号	8 期号:1 页码:139-144
关键词	colorectal cancer APC gene single nucleotide polymorphism genetic susceptibility
ISSN号	1792-1074
英文摘要	Adenomatous polyposis coli (APC) gene polymorphisms are believed to contribute to tumor susceptibility. However, the association between genetic variants (A/T) in the APC gene D1822V polymorphism and colorectal cancer (CRC) susceptibility remains unknown. To determine this association, a case-control study was performed.. The genotype of the APC gene D1822V variants was analyzed by DNA sequencing in blood samples collected from 196 patients with CRC and 279 healthy subjects. There were no significant associations between the case and control groups in the distribution of AT [odds ratio (OR), 0.604; 95% confidence interval (CI), 0.355-1.029) and TT genotypes (OR, 0.438; 95% CI, 0.045-4.247) relative to the AA genotype. The ratio of the T allele was significantly lower (P=0.047) in the case group compared with the control group (OR, 0.611; 95% CI, 0.374-0.997), indicating that the T allele conferred a protective effect in CRC. The frequency of the AT genotype among the subjects diagnosed at >45 years of age was lower than those diagnosed at a younger age (P<0.05). The present study demonstrates that the T allele of the D1822V polymorphism may exert a protective effect against CRC, however, these findings require further validation in a larger sample size.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Oncology
研究领域[WOS]	Oncology
关键词[WOS]	KSP-CADHERIN ; LI-CADHERIN ; RISK ; POLYMORPHISMS ; PREDISPOSITION ; ALLELES ; PROTEIN ; STYLE ; DNA
收录类别	SCI
语种	英语
WOS记录号	WOS:000338179100025
公开日期	2015-01-20
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/20387]
专题	水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
作者单位	1.Wuhan Univ, Dept Oncol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China 2.Cent Hosp Enshi Prefecture, Dept Oncol, Enshi 445000, Hubei, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Feng, Maohui,Fang, Xiping,Yang, Qian,et al. Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer[J]. ONCOLOGY LETTERS,2014,8(1):139-144.
APA	Feng, Maohui.,Fang, Xiping.,Yang, Qian.,Ouyang, Gang.,Chen, Daping.,...&Xie, Wei.(2014).Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer.ONCOLOGY LETTERS,8(1),139-144.
MLA	Feng, Maohui,et al."Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer".ONCOLOGY LETTERS 8.1(2014):139-144.