Optical Imaging of Visual Cortical Responses Evoked by Transcorneal Electrical Stimulation With Different Parameters

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Optical Imaging of Visual Cortical Responses Evoked by Transcorneal Electrical Stimulation With Different Parameters
	Ma, ZG ; Cao, PJ ; Sun, PC ; Li, LM ; Lu, YL ; Yan, Y ; Chen, Y ; Chai, XY
刊名	INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
	2014
卷号	55 期号:8 页码:5320-5331
关键词	RETINITIS-PIGMENTOSA RETINAL DEGENERATION NEURONAL-ACTIVITY RETINOTOPIC ORGANIZATION MORPHOMETRIC-ANALYSIS INTRINSIC SIGNALS SYSTEM EER BLOOD-FLOW MACAQUE V4 CAT
ISSN号	0146-0404
通讯作者	Chai, XY (reprint author), Wenxuan Med Bldg,RM 503 800 Dongchuan Rd, Shanghai 200240, Peoples R China.,yao.chen@sjtu.edu.cn
英文摘要	PURPOSE. The use of phosphenes evoked by transcorneal electrical stimulation (TcES) has been proposed as a means of residual visual function evaluation and candidate selection before implantation of retinal prostheses. Compared to the subjective measures, measurement of neuronal activity in visual cortex can objectively and quantitatively explore their response properties to electrical stimulation. The purpose of this study was to investigate systematically the properties of cortical responses evoked by TcES. METHODS. The visual cortical responses were recorded using a multiwavelength optical imaging of intrinsic signals (OIS) combining with electrophysiological recording by a multichannel electrode array. The effects of different parameters of TcES on cortical responses, including the changes of hemoglobin oxygenation and cerebral blood volume, were examined. RESULTS. We found consistent OIS activation regions in visual cortex after TcES, which also showed strong evoked field potentials according to electrophysiological results. The OIS response regions were located mainly in cortical areas representing peripheral visual field. The extent of activation areas and strength of intrinsic signals were increased with higher current intensities and longer pulse widths, and the largest responses were acquired in the frequency range 10 to 20 Hz. CONCLUSIONS. Use of TcES through the ERG-jet corneal electrode may preferentially activate peripheral retina. Revealing the hemodynamic changes in visual cortex occurred after electrical stimulation can contribute to comprehension of neurophysiological underpinnings underlying prosthetic vision. This study provided an objective foundation for optimizing parameters of TcES and would bring considerable benefits in the application of TcES for assessment and screening in patients.
学科主题	Ophthalmology
收录类别	SCI
资助信息	National Basic Research Program of China (973 Program) [2011CB707503/2]; National Natural Science Foundation of China [61273368, 91120304, 61171174]; National High Technology Research and Development Program of China (863 Program) [2009AA04Z326]; Shanghai Municipal Physical Culture Bureau Scientific and Technological Project [11JT010]; 111 Project from the Ministry of Education of China [B08020]
语种	英语
公开日期	2014-12-15
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2649]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Ma, ZG,Cao, PJ,Sun, PC,et al. Optical Imaging of Visual Cortical Responses Evoked by Transcorneal Electrical Stimulation With Different Parameters[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2014,55(8):5320-5331.
APA	Ma, ZG.,Cao, PJ.,Sun, PC.,Li, LM.,Lu, YL.,...&Chai, XY.(2014).Optical Imaging of Visual Cortical Responses Evoked by Transcorneal Electrical Stimulation With Different Parameters.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,55(8),5320-5331.
MLA	Ma, ZG,et al."Optical Imaging of Visual Cortical Responses Evoked by Transcorneal Electrical Stimulation With Different Parameters".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55.8(2014):5320-5331.