SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain
	Li, J ; Li, CM ; Zhang, DS ; Shi, D ; Qi, M ; Feng, J ; Yuan, TY ; Xu, XR ; Liang, DD ; Xu, L ; Zhang, H ; Liu, Y ; Chen, JJ ; Ye, JC ; Jiang, WF ; Cui, YY ; Zhang, YY ; Peng, LY ; Zhou, ZNA ; Chen, YH
刊名	NATURE COMMUNICATIONS
	2014
卷号	5 期号:1 页码:5177-5177
关键词	CELL-DEATH DISEASE ARC CARDIOPROTECTION BINDING PATHWAY NEXIN
ISSN号	2041-1723
通讯作者	Chen, YH (reprint author), Tongji Univ, East Hosp, Sch Med, Key Lab Arrhythmias,Minist Educ China, Shanghai 200120, Peoples R China.,yihanchen@tongji.edu.cn
英文摘要	Heart failure (HF) is associated with complicated molecular remodelling within cardiomyocytes; however, the mechanisms underlying this process remain unclear. Here we show that sorting nexin-13 (SNX13), a member of both the sorting nexin and the regulator of G protein signalling (RGS) protein families, is a potent mediator of HF. Decreased levels of SNX13 are observed in failing hearts of humans and of experimental animals. SNX13-deficient zebrafish recapitulate HF with striking cardiomyocyte apoptosis. Mechanistically, a reduction in SNX13 expression facilitates the degradative sorting of apoptosis repressor with caspase recruitment domain (ARC), which is a multifunctional inhibitor of apoptosis. Consequently, the apoptotic pathway is activated, resulting in the loss of cardiac cells and the dampening of cardiac function. The N-terminal PXA structure of SNX13 is responsible for mediating the endosomal trafficking of ARC. Thus, this study reveals that SNX13 profoundly affects cardiac performance through the SNX13-PXA-ARC-caspase signalling pathway.
学科主题	Multidisciplinary Sciences
收录类别	SCI
资助信息	National Key Basic Research Program of China [2013CB531100]; Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81221001]; Major International Joint Research Program Fund of China [81120108004]; National Natural Science Foundation of China [81170224, 81270313, 31271214]; Shanghai Natural Science Fund [10JC1414700]
语种	英语
公开日期	2014-12-15
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2641]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Li, J,Li, CM,Zhang, DS,et al. SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain[J]. NATURE COMMUNICATIONS,2014,5(1):5177-5177.
APA	Li, J.,Li, CM.,Zhang, DS.,Shi, D.,Qi, M.,...&Chen, YH.(2014).SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain.NATURE COMMUNICATIONS,5(1),5177-5177.
MLA	Li, J,et al."SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain".NATURE COMMUNICATIONS 5.1(2014):5177-5177.