Medial prefrontal activity during delay period contributes to learning of a working memory task

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	Medial prefrontal activity during delay period contributes to learning of a working memory task
	Liu, D ; Gu, XW ; Zhu, J ; Zhang, XX ; Han, Z ; Yan, WJ ; Cheng, Q ; Hao, J ; Fan, HM ; Hou, RQ ; Chen, ZQ ; Chen, YL ; Li, CYT
刊名	SCIENCE
	2014
卷号	346 期号:6208 页码:458-463
关键词	SHORT-TERM-MEMORY NEURAL MECHANISMS CORTICAL ACTIVITY CORTEX DYNAMICS DECISION RAT INFORMATION ACQUISITION LESIONS
ISSN号	0036-8075
通讯作者	Li, CYT (reprint author), Friedrich Miescher Inst Biomed Res, Maulbeerstr 66, CH-4058 Basel, Switzerland.,tonylicy@ion.ac.cn
英文摘要	Cognitive processes require working memory (WM) that involves a brief period of memory retention known as the delay period. Elevated delay-period activity in the medial prefrontal cortex (mPFC) has been observed, but its functional role in WM tasks remains unclear. We optogenetically suppressed or enhanced activity of pyramidal neurons in mouse mPFC during the delay period. Behavioral performance was impaired during the learning phase but not after the mice were well trained. Delay-period mPFC activity appeared to be more important in memory retention than in inhibitory control, decision-making, or motor selection. Furthermore, endogenous delay-period mPFC activity showed more prominent modulation that correlated with memory retention and behavioral performance. Thus, properly regulated mPFC delay-period activity is critical for information retention during learning of a WM task.
学科主题	Multidisciplinary Sciences
收录类别	SCI
资助信息	Chinese 973 Program [2011CBA00406]; State Key Laboratory of Neuroscience; Chinese Academy of Sciences Hundreds of Talents Program
语种	英语
公开日期	2014-12-15
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2638]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Liu, D,Gu, XW,Zhu, J,et al. Medial prefrontal activity during delay period contributes to learning of a working memory task[J]. SCIENCE,2014,346(6208):458-463.
APA	Liu, D.,Gu, XW.,Zhu, J.,Zhang, XX.,Han, Z.,...&Li, CYT.(2014).Medial prefrontal activity during delay period contributes to learning of a working memory task.SCIENCE,346(6208),458-463.
MLA	Liu, D,et al."Medial prefrontal activity during delay period contributes to learning of a working memory task".SCIENCE 346.6208(2014):458-463.