Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides
	Wu, Hai-Yan 1,2; Wang, Wei-Guang 1; Jiang, Hua-Yi 1,2; Du, Xue 1; Li, Xiao-Nian 1; Pu, Jian-Xin1 ; Sun, Han-Dong1
刊名	FITOTERAPIA
	2014-10-01
卷号	98 页码:192-198
关键词	Lamiaceae Isodon wikstroemioides ent-Kaurane diterpenoid Cytotoxicity
ISSN号	0367-326X
通讯作者	Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn
产权排序	第一
英文摘要	Seven new ent-kaurane diterpenoids, isowikstroemins A-G (1-7), were isolated from EtOAc extracts of the aerial parts of Isodon wikstroemioides. Their structures were elucidated by extensive spectroscopic analysis. The isolates were evaluated for their cytotoxicity against five human tumor cell lines, and compounds 1-4 exhibited significant activity with IC50 values ranging from 0.9 to 7.0 mu M. In addition, compounds 1, 2, 3, 4, and 7 exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. (C) 2014 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	WIKSTROEMIOIDES
收录类别	SCI
资助信息	National Natural Science Foundation of China [21322204, 81172939]; NSFC-Joint Foundation of Yunnan Province [U1302223]; Yunnan Province [2011C1043]; Major Direction Projection Foundation of CAS Intellectual Innovation Projec [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences
语种	英语
WOS记录号	WOS:000343617600028
公开日期	2014-11-25
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18382]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Hai-Yan,Wang, Wei-Guang,Jiang, Hua-Yi,et al. Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides[J]. FITOTERAPIA,2014,98:192-198.
APA	Wu, Hai-Yan.,Wang, Wei-Guang.,Jiang, Hua-Yi.,Du, Xue.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2014).Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides.FITOTERAPIA,98,192-198.
MLA	Wu, Hai-Yan,et al."Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides".FITOTERAPIA 98(2014):192-198.