Two new sesquiterpenes from Artemisia sieversiana

	Two new sesquiterpenes from Artemisia sieversiana
	Liu, Shi-Jun 1,3; Liao, Zhi-Xin 1,3; Liu, Chao 1; Ji, Lan-Ju 2; Sun, Hong-Fa 2
刊名	fitoterapia
	2014-09-01
卷号	97 页码:43-49
关键词	Artemisia sieversiana Compositae Sesquiterpene Lignan Flavone Cytotoxic activity
ISSN号	0367-326x
中文摘要	two new sesquiterpenes, together with 32 known compounds(3-34), were isolated from artemisia sieversiana ehrhart ex willd. and the compounds 3-21 were isolated from this plant for the first time. the new compounds were elucidated as 2a,9a-dihydroxymuurol-3(4)-en-12-oic acid (1) and 13 alpha-methyl-(5 alpha h,6 alpha h,7 alpha h,8 alpha h)-austricin 8-o-beta-d-glucopyranoside (2), respectively. the structural identification of these compounds was mainly achieved by spectroscopic methods including 1d and 2d nmr techniques, and the structure of compound 1 was confirmed by a single crystal x-ray diffraction experiment. compounds 1-2 were evaluated for cytotoxic activity in vitro against mcf-7, nci-h460 and hep-g2 cell lines, respectively. (c) 2014 elsevier b.v. all rights reserved.
英文摘要	two new sesquiterpenes, together with 32 known compounds(3-34), were isolated from artemisia sieversiana ehrhart ex willd. and the compounds 3-21 were isolated from this plant for the first time. the new compounds were elucidated as 2a,9a-dihydroxymuurol-3(4)-en-12-oic acid (1) and 13 alpha-methyl-(5 alpha h,6 alpha h,7 alpha h,8 alpha h)-austricin 8-o-beta-d-glucopyranoside (2), respectively. the structural identification of these compounds was mainly achieved by spectroscopic methods including 1d and 2d nmr techniques, and the structure of compound 1 was confirmed by a single crystal x-ray diffraction experiment. compounds 1-2 were evaluated for cytotoxic activity in vitro against mcf-7, nci-h460 and hep-g2 cell lines, respectively. (c) 2014 elsevier b.v. all rights reserved.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	chemistry, medicinal ; pharmacology & pharmacy
研究领域[WOS]	pharmacology & pharmacy
关键词[WOS]	cytotoxic activity ; constituents ; lactones ; leaves ; identification ; diterpenoids ; lignans ; tobacco ; bark
收录类别	SCI
语种	英语
WOS记录号	WOS:000341346400006
公开日期	2014-12-19
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/4194]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Southeast Univ, Dept Pharmaceut Engn, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810008, Peoples R China 3.Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Liu, Shi-Jun,Liao, Zhi-Xin,Liu, Chao,et al. Two new sesquiterpenes from Artemisia sieversiana[J]. fitoterapia,2014,97:43-49.
APA	Liu, Shi-Jun,Liao, Zhi-Xin,Liu, Chao,Ji, Lan-Ju,&Sun, Hong-Fa.(2014).Two new sesquiterpenes from Artemisia sieversiana.fitoterapia,97,43-49.
MLA	Liu, Shi-Jun,et al."Two new sesquiterpenes from Artemisia sieversiana".fitoterapia 97(2014):43-49.