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	Investigating the association between birth weight and complementary air pollution metrics: a cohort study
	Laurent O. ; Wu J. ; Li L. F. ; Chung J. ; Bartell S.
	2013
关键词	Birth weight Air pollution Exposure assessment Traffic Ozone los-angeles-county residential proximity socioeconomic-status particulate matter pregnancy outcomes regression-models traffic exposure fetal-growth california preterm
英文摘要	Background: Exposure to air pollution is frequently associated with reductions in birth weight but results of available studies vary widely, possibly in part because of differences in air pollution metrics. Further insight is needed to identify the air pollution metrics most strongly and consistently associated with birth weight. Methods: We used a hospital-based obstetric database of more than 70,000 births to study the relationships between air pollution and the risk of low birth weight (LBW, <2,500 g), as well as birth weight as a continuous variable, in term-born infants. Complementary metrics capturing different aspects of air pollution were used (measurements from ambient monitoring stations, predictions from land use regression models and from a Gaussian dispersion model, traffic density, and proximity to roads). Associations between air pollution metrics and birth outcomes were investigated using generalized additive models, adjusting for maternal age, parity, race/ethnicity, insurance status, poverty, gestational age and sex of the infants. Results: Increased risks of LBW were associated with ambient O-3 concentrations as measured by monitoring stations, as well as traffic density and proximity to major roadways. LBW was not significantly associated with other air pollution metrics, except that a decreased risk was associated with ambient NO2 concentrations as measured by monitoring stations. When birth weight was analyzed as a continuous variable, small increases in mean birth weight were associated with most air pollution metrics (<40 g per inter-quartile range in air pollution metrics). No such increase was observed for traffic density or proximity to major roadways, and a significant decrease in mean birth weight was associated with ambient O-3 concentrations. Conclusions: We found contrasting results according to the different air pollution metrics examined. Unmeasured confounders and/or measurement errors might have produced spurious positive associations between birth weight and some air pollution metrics. Despite this, ambient O-3 was associated with a decrement in mean birth weight and significant increases in the risk of LBW were associated with traffic density, proximity to roads and ambient O-3. This suggests that in our study population, these air pollution metrics are more likely related to increased risks of LBW than the other metrics we studied. Further studies are necessary to assess the consistency of such patterns across populations.
出处	Environmental Health
卷	12
收录类别	SCI
语种	英语
ISSN号	1476-069X
内容类型	SCI/SSCI论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/30464]
专题	地理科学与资源研究所_历年回溯文献
推荐引用方式 GB/T 7714	Laurent O.,Wu J.,Li L. F.,et al. Investigating the association between birth weight and complementary air pollution metrics: a cohort study. 2013.

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