Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis)

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	Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis)
	Xiang, ZM ; Qu, FF ; Li, J ; Qi, L ; Yang, Z ; Kong, XY ; Yu, ZN
刊名	FISH & SHELLFISH IMMUNOLOGY
	2014
卷号	36 期号:1 页码:83-89
关键词	Crassostrea hongkongensis Immunity ChAP-1
ISSN号	1050-4648
通讯作者	carlzyu@scsio.ac.cn
中文摘要	Growing evidence suggests that the transcription factor activator protein-1 (AP-1), a downstream target of mitogen-activated protein kinase (MAPK) signaling, plays a major role in stimulating the synthesis of immune effector molecules during innate immune responses. We have characterized ChAP-1, an AP-1-like protein in Crassostrea hongkongensis that is a member of the AP-1 family of proteins. ChAP-1 is composed of 290 amino acid residues with a Jun and bZIP domain at the N- and C-termini, respectively, a structure similar to that of known Ap-1 proteins. ChAP-1 mRNA is expressed in several tissues analyzed, with highest expression in the mantle. Expression of ChAP-1 increases in response to Vibrio alginolyticus, Salmo haemolyticus or Salmo cerevisiae infection and, despite the location of GFP-tagged full-length ChAP-1 protein in the cytoplasm, ChAP-1 activates the transcription of an L8G5-luc reporter gene, and its overexpression can also activate the AP-1-Luc reporter gene in HEK293T cells. (C) 2013 Elsevier Ltd. All rights reserved.
学科主题	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
收录类别	SCI
资助信息	National Science Foundation of China [31202021, 31001130, 41176150]; National Basic Research Program of China [2010CB126404]; Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China [2013J2200095]
原文出处	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号	WOS:000331671600011
公开日期	2014-12-11
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10492]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Xiang, ZM,Qu, FF,Li, J,et al. Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis)[J]. FISH & SHELLFISH IMMUNOLOGY,2014,36(1):83-89.
APA	Xiang, ZM.,Qu, FF.,Li, J.,Qi, L.,Yang, Z.,...&Yu, ZN.(2014).Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis).FISH & SHELLFISH IMMUNOLOGY,36(1),83-89.
MLA	Xiang, ZM,et al."Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis)".FISH & SHELLFISH IMMUNOLOGY 36.1(2014):83-89.