Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208

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	Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208
	Ai, W ; Lin, XP ; Tu, ZC ; Tian, XP ; Lu, X ; Mangaladoss, F ; Zhong, ZL ; Liu, YH
刊名	NATURAL PRODUCT RESEARCH
	2014
卷号	28 期号:16 页码:1219-1224
关键词	Streptomyces axinellae COX-2 inhibitor
ISSN号	1478-6419
通讯作者	yonghongliu@scsio.ac.cn
中文摘要	Axinelline A, a new cyclooxygenase-2 (COX-2) inhibitor, was isolated from Streptomyces axinellae SCSIO02208. The structures of compounds 1-9 were determined by analysing the NMR and MS data. The absolute configuration of 1 was determined by using optical rotation and comparing with the reported data. Compound 1 exhibited COX-2 inhibitory activity, the IC50 value being 2.8 mu M.
学科主题	Chemistry ; Pharmacology & Pharmacy
收录类别	SCI
资助信息	National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
原文出处	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000340267000001
公开日期	2014-12-11
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10480]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Ai, W,Lin, XP,Tu, ZC,et al. Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208[J]. NATURAL PRODUCT RESEARCH,2014,28(16):1219-1224.
APA	Ai, W.,Lin, XP.,Tu, ZC.,Tian, XP.,Lu, X.,...&Liu, YH.(2014).Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208.NATURAL PRODUCT RESEARCH,28(16),1219-1224.
MLA	Ai, W,et al."Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208".NATURAL PRODUCT RESEARCH 28.16(2014):1219-1224.