The synthetic progestin megestrol acetate adversely affects zebrafish reproduction

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	The synthetic progestin megestrol acetate adversely affects zebrafish reproduction
	Han, J ; Wang, QW ; Wang, XF ; Li, YG ; Wen, S ; Liu, S ; Ying, GG ; Guo, YY ; Zhou, BS
刊名	AQUATIC TOXICOLOGY
	2014
卷号	150 页码:66-72
关键词	Progestin Endocrine disruption Reproduction Hypothalamic-pituitary-gonadal axis
ISSN号	0166-445X
通讯作者	bszhou@ihb.ac.cn
中文摘要	Synthetic progestins contaminate the aquatic ecosystem, and may cause adverse health effects on aquatic organisms. Megestrol acetate (MTA) is present in the aquatic environment, but its possible effects on fish reproduction are unknown. In the present study, we investigated the endocrine disruption and impact of MTA on fish reproduction. After a pre-exposure period of 14 days, reproductively mature zebrafish (Danio rerio) (F0) were exposed to MTA at environmental concentrations (33, 100, 333, and 666 ng/L) for 21 days. Egg production was decreased in F0 fish exposed to MTA, with a significant decrease at 666 ng/L. The exposure significantly decreased the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-keto testosterone (11-KT) in male fish. MTA exposure significantly downregulated the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. MTA did not affect early embryonic development or hatching success in the F1 generation. The present study showed that MTA is a potent endocrine disruptor in fish, and short-term exposure to MTA could significantly affect reproduction in fish and negatively impact the fish population. (C) 2014 Elsevier B.V. All rights reserved.
学科主题	Marine & Freshwater Biology ; Toxicology
收录类别	SCI
资助信息	National Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13]
原文出处	ELSEVIER SCIENCE BV
WOS记录号	WOS:000336187900008
公开日期	2014-12-11
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10443]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Han, J,Wang, QW,Wang, XF,et al. The synthetic progestin megestrol acetate adversely affects zebrafish reproduction[J]. AQUATIC TOXICOLOGY,2014,150:66-72.
APA	Han, J.,Wang, QW.,Wang, XF.,Li, YG.,Wen, S.,...&Zhou, BS.(2014).The synthetic progestin megestrol acetate adversely affects zebrafish reproduction.AQUATIC TOXICOLOGY,150,66-72.
MLA	Han, J,et al."The synthetic progestin megestrol acetate adversely affects zebrafish reproduction".AQUATIC TOXICOLOGY 150(2014):66-72.