Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors
	Ai, W ; Wei, XY ; Lin, XP ; Sheng, L ; Wang, Z ; Tu, ZC ; Yang, XW ; Zhou, XF ; Li, J ; Liu, YH
刊名	TETRAHEDRON
	2014
卷号	70 期号:35 页码:5806-5814
关键词	Spirodioxynaphthalene Kandelia candel Mangrove plant Endophytic fungus Guignardia sp.
ISSN号	0040-4020
通讯作者	jli@mail.shcnc.ac.cn ; yonghongliu@scsio.ac.cn
中文摘要	Six new guignardins A-F (1-6) were isolated from the cultures of endophytic fungus Guignardia sp. KcF8 derived of a mangrove plant Kandelia candel, along with three known analogues, palmarumycins C-1 (7), BG1 (8), and JC1 (9). Compounds 2, 3, 7, and 8 showed antimicrobial activities. Compounds 5-7 exhibited significant cytotoxicities against 10 human tumor cell lines. Compound 3 also displayed significant inhibitory activity against human protein tyrosine phosphatase 1B and histone deacetylase silent information regulator T-1 enzymes, two key targets for the treatment of diabetes. This is the first report on the anti-PTP1B and anti-SIRT1 activities of spirodioxynaphthalenes. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Chemistry
收录类别	SCI
资助信息	National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2013AA092901, 2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
原文出处	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000340336000055
公开日期	2014-12-11
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10385]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Ai, W,Wei, XY,Lin, XP,et al. Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors[J]. TETRAHEDRON,2014,70(35):5806-5814.
APA	Ai, W.,Wei, XY.,Lin, XP.,Sheng, L.,Wang, Z.,...&Liu, YH.(2014).Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors.TETRAHEDRON,70(35),5806-5814.
MLA	Ai, W,et al."Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors".TETRAHEDRON 70.35(2014):5806-5814.