DNA display for drug discovery

	DNA display for drug discovery
	Chen, Haodong ; Chen, Gangyi ; Du, Feng ; Fu, Qingquan ; Zhao, Yun ; Tang, Zhuo
刊名	RSC ADVANCES
	2013
卷号	3 期号:37 页码:16251-16254
ISSN号	2046-2069
通讯作者	Tang, Z (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Peoples R China.
产权排序	1
英文摘要	A novel DNA display strategy, based on a new puromycin modifier, has been developed. The 5'-end puromycin-tethered oligonucleotide was synthesized to hybridize with mRNA, so that it could attack the nascent polypeptides during in vitro translation. The DNA-peptide fusion molecule can tolerate more harsh and stringent selection conditions, therefore, this DNA display may become a useful tool for in vitro display technologies for the selection of peptide drug candidates.
学科主题	Chemistry
收录类别	SCI
语种	英语
WOS记录号	WOS:000323842900005
公开日期	2014-11-21
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/24185]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Chen, Haodong,Chen, Gangyi,Du, Feng,et al. DNA display for drug discovery[J]. RSC ADVANCES,2013,3(37):16251-16254.
APA	Chen, Haodong,Chen, Gangyi,Du, Feng,Fu, Qingquan,Zhao, Yun,&Tang, Zhuo.(2013).DNA display for drug discovery.RSC ADVANCES,3(37),16251-16254.
MLA	Chen, Haodong,et al."DNA display for drug discovery".RSC ADVANCES 3.37(2013):16251-16254.