Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools

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	Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools
	Zhao, Fenfang 1,2; Shen, Guizhi 1; Chen, Chengjun 1; Xing, Ruirui 1; Zou, Qianli 1; Ma, Guanghui 1; Yan, Xuehai 1
刊名	CHEMISTRY-A EUROPEAN JOURNAL
	2014-06-02
卷号	20 期号:23 页码:6880-6887
关键词	colloids drug delivery nanostructures polypeptides proteins
ISSN号	0947-6539
其他题名	Chem.-Eur. J.
中文摘要	We present a general strategy to nanoengineer protein-based colloidal spheres (biomimetic protocells) as versatile delivery carriers with stimuli responsiveness by the electrostatic assembly of binary components (proteins and polypeptides) in association with intermolecular disulfide cross-linking. The size of the colloidal spheres, ranging from nanoscale to microscale, is readily tuned through parameters like protein and polypeptide concentration, the ratio between both, pH, and so on. Moreover, such colloidal spheres show versatile encapsulation of various guest molecules including small organic molecules and biomacromolecules. The pH and redox dual-responsiveness facilitates the rapid release of the payload in an acidic and reductant-enriched ambient such as in lysosomes. Thus, nanoengineering of protein-based biomimetic protocells opens a new alternative avenue for developing delivery vehicles with multifunctional properties towards a range of therapeutic and diagnostic applications.
英文摘要	We present a general strategy to nanoengineer protein-based colloidal spheres (biomimetic protocells) as versatile delivery carriers with stimuli responsiveness by the electrostatic assembly of binary components (proteins and polypeptides) in association with intermolecular disulfide cross-linking. The size of the colloidal spheres, ranging from nanoscale to microscale, is readily tuned through parameters like protein and polypeptide concentration, the ratio between both, pH, and so on. Moreover, such colloidal spheres show versatile encapsulation of various guest molecules including small organic molecules and biomacromolecules. The pH and redox dual-responsiveness facilitates the rapid release of the payload in an acidic and reductant-enriched ambient such as in lysosomes. Thus, nanoengineering of protein-based biomimetic protocells opens a new alternative avenue for developing delivery vehicles with multifunctional properties towards a range of therapeutic and diagnostic applications.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	ALBUMIN HSA NANOPARTICLES ; SERUM-ALBUMIN ; MICROCAPSULES ; RELEASE ; SPHERES ; SHELLS ; PH ; DOXORUBICIN ; ASSEMBLIES ; REDUCTION
收录类别	SCI
原文出处	://WOS:000337574800010
语种	英语
WOS记录号	WOS:000337574800010
公开日期	2014-08-28
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/11049]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Fenfang,Shen, Guizhi,Chen, Chengjun,et al. Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools[J]. CHEMISTRY-A EUROPEAN JOURNAL,2014,20(23):6880-6887.
APA	Zhao, Fenfang.,Shen, Guizhi.,Chen, Chengjun.,Xing, Ruirui.,Zou, Qianli.,...&Yan, Xuehai.(2014).Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools.CHEMISTRY-A EUROPEAN JOURNAL,20(23),6880-6887.
MLA	Zhao, Fenfang,et al."Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools".CHEMISTRY-A EUROPEAN JOURNAL 20.23(2014):6880-6887.