QQ客服 官方微博 反馈留言

	Novel Vaccine Delivery System Induces Robust Humoral and Cellular Immune Responses Based on Multiple Mechanisms
	Wang, Yue-Qi1,2; Wu, Jie1; Fan, Qing-Ze1,2; Zhou, Meng1; Yue, Zhan-Guo1,2; Ma, Guang-Hui1; Su, Zhi-Guo1
刊名	ADVANCED HEALTHCARE MATERIALS
	2014-05-01
卷号	3期号:5页码:670-681
关键词	hydrogels particulate delivery system adjuvants quaternized chitosan H5N1 split vaccines
ISSN号	2192-2640
其他题名	Adv. Healthc. Mater.
中文摘要	Aiming to enhance the immunogenicity of H5N1 split vaccine, the development of a novel antigen delivery system based on quaternized chitosan hydrogel microparticles (Gel MPs) with multiple mechanisms of immunity enhancement is attempted. Gel MPs based on ionic cross-linking are prepared in a simple and mild way. Gel MPs are superior as a vaccine delivery system due to their ability to: 1) enhance cellular uptake and endosomal escape of antigens in dendritic cells (DCs); 2) significantly activate DCs; 3) form an antigen depot and recruit immunity cells to improve antigen capture. Further in vivo investigation shows that Gel MPs, in comparison to aluminum salts (Alum), LPS, and covalent cross-linking quaternized chitosan MPs (GC MPs), induce higher humoral and cellular immune responses with a mixed Th1/Th2 immunity. In conclusion, these results demonstrate that Gel MPs are efficient antigen delivery vehicles based on multiple mechanisms to enhance both humoral and cellular immune responses against H5N1 split antigen.
英文摘要	Aiming to enhance the immunogenicity of H5N1 split vaccine, the development of a novel antigen delivery system based on quaternized chitosan hydrogel microparticles (Gel MPs) with multiple mechanisms of immunity enhancement is attempted. Gel MPs based on ionic cross-linking are prepared in a simple and mild way. Gel MPs are superior as a vaccine delivery system due to their ability to: 1) enhance cellular uptake and endosomal escape of antigens in dendritic cells (DCs); 2) significantly activate DCs; 3) form an antigen depot and recruit immunity cells to improve antigen capture. Further in vivo investigation shows that Gel MPs, in comparison to aluminum salts (Alum), LPS, and covalent cross-linking quaternized chitosan MPs (GC MPs), induce higher humoral and cellular immune responses with a mixed Th1/Th2 immunity. In conclusion, these results demonstrate that Gel MPs are efficient antigen delivery vehicles based on multiple mechanisms to enhance both humoral and cellular immune responses against H5N1 split antigen.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Materials Science, Biomaterials
研究领域[WOS]	Materials Science
关键词[WOS]	DENDRITIC CELLS ; INFLUENZA VACCINES ; VIRAL-INFECTION ; DRUG-DELIVERY ; H5N1 VIRUS ; IN-VITRO ; T-CELLS ; CHITOSAN ; ADJUVANT ; ACTIVATION
收录类别	SCI
原文出处	://WOS:000335730200005
语种	英语
WOS记录号	WOS:000335730200005
公开日期	2014-08-28
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/10986]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Key Lab Biopharmaceut Prod & Formulat Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yue-Qi,Wu, Jie,Fan, Qing-Ze,et al. Novel Vaccine Delivery System Induces Robust Humoral and Cellular Immune Responses Based on Multiple Mechanisms[J]. ADVANCED HEALTHCARE MATERIALS,2014,3(5):670-681.
APA	Wang, Yue-Qi.,Wu, Jie.,Fan, Qing-Ze.,Zhou, Meng.,Yue, Zhan-Guo.,...&Su, Zhi-Guo.(2014).Novel Vaccine Delivery System Induces Robust Humoral and Cellular Immune Responses Based on Multiple Mechanisms.ADVANCED HEALTHCARE MATERIALS,3(5),670-681.
MLA	Wang, Yue-Qi,et al."Novel Vaccine Delivery System Induces Robust Humoral and Cellular Immune Responses Based on Multiple Mechanisms".ADVANCED HEALTHCARE MATERIALS 3.5(2014):670-681.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。