Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders
	Zhang, Y ; Mao, RR ; Chen, ZF ; Tian, M ; Tong, DL ; Gao, ZR ; Huang, M ; Li, X ; Xu, X ; Zhou, WH ; Li, CY ; Wang, J ; Xu, L ; Qiu, ZL
刊名	MOLECULAR BRAIN
	2014
卷号	7 期号:1 页码:2940-2956
关键词	LONG-TERM POTENTIATION CPG-BINDING PROTEIN-2 HUMAN MOTOR CORTEX RETT-SYNDROME DENTATE GYRUS ANTIDEPRESSANT TREATMENT ENHANCES NEUROGENESIS SYNAPTIC DEPRESSION RAT HIPPOCAMPUS IN-VIVO
ISSN号	1756-6606
通讯作者	Xu, L (reprint author), Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China.,lxu@vip.163.com
英文摘要	Background: Repetitive Transcranial Magnetic Stimulation (rTMS)/ Deep-brain Magnetic Stimulation (DMS) is an effective therapy for various neuropsychiatric disorders including major depression disorder. The molecular and cellular mechanisms underlying the impacts of rTMS/DMS on the brain are not yet fully understood. Results: Here we studied the effects of deep-brain magnetic stimulation to brain on the molecular and cellular level. We examined the adult hippocampal neurogenesis and hippocampal synaptic plasticity of rodent under stress conditions with deep-brain magnetic stimulation treatment. We found that DMS promotes adult hippocampal neurogenesis significantly and facilitates the development of adult new-born neurons. Remarkably, DMS exerts anti-depression effects in the learned helplessness mouse model and rescues hippocampal long-term plasticity impaired by restraint stress in rats. Moreover, DMS alleviates the stress response in a mouse model for Rett syndrome and prolongs the life span of these animals dramatically. Conclusions: Deep-brain magnetic stimulation greatly facilitates adult hippocampal neurogenesis and maturation, also alleviates depression and stress-related responses in animal models.
学科主题	Neurosciences
收录类别	SCI
资助信息	National Basic Research Program of China [2011CBA00400, 2013CB835103, 2009CB941302]; CAS Hundreds of Talents Program; Chinese Academy of Sciences [XDB02050400]; National Natural Science Foundation of China [U1032605, 31100786]
语种	英语
公开日期	2014-07-30
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2624]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhang, Y,Mao, RR,Chen, ZF,et al. Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders[J]. MOLECULAR BRAIN,2014,7(1):2940-2956.
APA	Zhang, Y.,Mao, RR.,Chen, ZF.,Tian, M.,Tong, DL.,...&Qiu, ZL.(2014).Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders.MOLECULAR BRAIN,7(1),2940-2956.
MLA	Zhang, Y,et al."Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders".MOLECULAR BRAIN 7.1(2014):2940-2956.