Parallel pathways convey olfactory information with opposite polarities in Drosophila

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	Parallel pathways convey olfactory information with opposite polarities in Drosophila
	Wang, KY ; Gong, JX ; Wang, QX ; Li, H ; Cheng, Q ; Liu, YF ; Zeng, SQ ; Wang, ZR
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2014
卷号	111 期号:8 页码:3164-3169
关键词	ANTENNAL LOBE PROJECTION NEURONS COURTSHIP BEHAVIOR MUSHROOM BODIES MANDUCA-SEXTA BRAIN MELANOGASTER HONEYBEE SYSTEM FLY
ISSN号	0027-8424
通讯作者	Wang, ZR (reprint author), Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,zuorenwang@ion.ac.cn
英文摘要	In insects, olfactory information received by peripheral olfactory receptor neurons (ORNs) is conveyed from the antennal lobes (ALs) to higher brain regions by olfactory projection neurons (PNs). Despite the knowledge that multiple types of PNs exist, little is known about how these different neuronal pathways work cooperatively. Here we studied the Drosophila GABAergic mediolateral antennocerebral tract PNs (mlPNs), which link ipsilateral AL and lateral horn (LH), in comparison with the cholinergic medial tract PNs (mPNs). We examined the connectivity of mlPNs in ALs and found that most mlPNs received inputs from both ORNs and mPNs and participated in AL network function by forming gap junctions with other AL neurons. Meanwhile, mlPNs might innervate LH neurons downstream of mPNs, exerting a feedforward inhibition. Using dual-color calcium imaging, which enables a simultaneous monitoring of neural activities in two groups of PNs, we found that mlPNs exhibited robust odor responses overlapping with, but broader than, those of mPNs. Moreover, preferentially down-regulation of GABA in most mlPNs caused abnormal courtship and aggressive behaviors in male flies. These findings demonstrate that in Drosophila, olfactory information in opposite polarities are carried coordinately by two parallel and interacted pathways, which could be essential for appropriate behaviors.
学科主题	Multidisciplinary Sciences
收录类别	SCI
资助信息	Chinese Academy of Sciences [XDB02010005]; China 973 Project [2011CBA0040]; National Nature Science Foundation of China [30925013, 81327802]
语种	英语
公开日期	2014-07-30
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2622]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Wang, KY,Gong, JX,Wang, QX,et al. Parallel pathways convey olfactory information with opposite polarities in Drosophila[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014,111(8):3164-3169.
APA	Wang, KY.,Gong, JX.,Wang, QX.,Li, H.,Cheng, Q.,...&Wang, ZR.(2014).Parallel pathways convey olfactory information with opposite polarities in Drosophila.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,111(8),3164-3169.
MLA	Wang, KY,et al."Parallel pathways convey olfactory information with opposite polarities in Drosophila".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111.8(2014):3164-3169.