Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila

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	Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila
	Lin, JY ; Wang, WA ; Zhang, X ; Liu, HY ; Zhao, XL ; Huang, FD
刊名	NEUROSCIENCE BULLETIN
	2014
卷号	30 期号:2 页码:185-190
关键词	ALZHEIMERS-DISEASE AMYLOID-BETA A-BETA SYNAPTIC-TRANSMISSION ACTIVE ZONE PROTEIN EXPRESSION OLIGOMERS MODEL NEURODEGENERATION
ISSN号	1673-7067
通讯作者	Huang, FD (reprint author), Chinese Acad Sci, Shanghai Adv Res Inst, Ctr Stem Cell & Nanomed, Lab Syst Biol, Shanghai 201210, Peoples R China.,wangwenan312141030@163.com ; huangfude@yahoo.com
英文摘要	Beta amyloid (A beta(42))-induced dysfunction and loss of synapses are believed to be major underlying mechanisms for the progressive loss of learning and memory abilities in Alzheimer's disease (AD). The vast majority of investigations on AD-related synaptic impairment focus on synaptic plasticity, especially the decline of long-term potentiation of synaptic transmission caused by extracellular A beta(42). Changes in other aspects of synaptic and neuronal functions are less studied or undiscovered. Here, we report that intraneuronal accumulation of A beta(42) induced an age-dependent slowing of neuronal transmission along pathways involving multiple synapses.
学科主题	Neurosciences
收录类别	SCI
资助信息	National Natural Science Foundation of China [81071026, 81371400]; National Basic Research Development Program of China [2013CB530900]
语种	英语
公开日期	2014-07-30
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2613]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Lin, JY,Wang, WA,Zhang, X,et al. Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila[J]. NEUROSCIENCE BULLETIN,2014,30(2):185-190.
APA	Lin, JY,Wang, WA,Zhang, X,Liu, HY,Zhao, XL,&Huang, FD.(2014).Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila.NEUROSCIENCE BULLETIN,30(2),185-190.
MLA	Lin, JY,et al."Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila".NEUROSCIENCE BULLETIN 30.2(2014):185-190.