Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides

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	Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides
	Wu, Hai-Yan 1,2; Zhan, Rui 1; Wang, Wei-Guang 1; Jiang, Hua-Yi 1,2; Du, Xue 1; Li, Xiao-Nian 1; Li, Yan1 ; Pu, Jian-Xin1 ; Sun, Han-Dong1
刊名	JOURNAL OF NATURAL PRODUCTS
	2014-04-01
卷号	77 期号:4 页码:931-941
关键词	RUBESCENS VAR.-TAIHANGENSIS KAURENE DITERPENOIDS MAOECRYSTAL-V C-H ERIOCALYX SKELETON
ISSN号	0163-3864
通讯作者	Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn
英文摘要	Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E-V, 1-18), along with 17 known analogues (19-35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction analysis. The isolates were screened against five human tumor cell lines; compounds 3, 4, 9, 11-13, 23, 25-28, and 33 exhibited significant cytotoxic activity against all five, with IC50 values ranging from 0.4 to 5.1 mu M. In addition, 17 of the isolates strongly inhibited nitric oxide production in LPS-activated RAW264.7 macrophages.
学科主题	Plant Sciences ; Pharmacology & Pharmacy
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	RUBESCENS VAR.-TAIHANGENSIS ; KAURENE DITERPENOIDS ; MAOECRYSTAL-V ; C-H ; ERIOCALYX ; SKELETON
收录类别	SCI ; IC
资助信息	National Natural Science Foundation of China [21322204, 81172939]; NSFC-Joint Foundation of Yunnan Province [U1302223]; Reservation-Talent Project of Yunnan Province [2011CI043]; Major Direction Projection Foundation of CAS Intellectual Innovation Project [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences
语种	英语
WOS记录号	WOS:000335127200027
公开日期	2014-06-23
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18122]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Hai-Yan,Zhan, Rui,Wang, Wei-Guang,et al. Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):931-941.
APA	Wu, Hai-Yan.,Zhan, Rui.,Wang, Wei-Guang.,Jiang, Hua-Yi.,Du, Xue.,...&Sun, Han-Dong.(2014).Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides.JOURNAL OF NATURAL PRODUCTS,77(4),931-941.
MLA	Wu, Hai-Yan,et al."Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides".JOURNAL OF NATURAL PRODUCTS 77.4(2014):931-941.