Substituent contribution to the genotoxicity of benzophenone-type UV filters

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Substituent contribution to the genotoxicity of benzophenone-type UV filters
	Zhao, Huimin ; Wei, Dongbin ; Li, Min ; Du, Yuguo
刊名	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
	2013
卷号	95 期号:1 页码:241-246
通讯作者	Wei, DB
中文摘要	Benzophenones (Bps) are widely used in UV filters, fragrance enhancers, and plastic additives. In this study, the genotoxicity of 14 BPs was tested using the SOS/umu assay, and the related substituent contribution was disclosed. The results of this study revealed that the major contributor to the genotoxicity of the BPs was the ortho,para-di-substitution, and the increasing hydroxy substitution on the benzene ring. In addition, the higher the dispersion of the substituent species on the two benzene rings, the lower the genotoxicity exhibited by the compound. Furthermore, 2 dimensional and 3 dimenional quantitative structure activity relationships (2D- and 3D-QSAR) studies indicated that hydrogen-bond interactions and electrostatic effects were determinants for the genotoxicity of the BPs. The current results provide useful information for the assessment of the potential ecological risk and health effects of BP-type UV filters. (C) 2013 Elsevier Inc. All rights reserved.
收录类别	SCI
WOS记录号	WOS:000322286400031
公开日期	2014-06-06
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/7478]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zhao, Huimin,Wei, Dongbin,Li, Min,et al. Substituent contribution to the genotoxicity of benzophenone-type UV filters[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2013,95(1):241-246.
APA	Zhao, Huimin,Wei, Dongbin,Li, Min,&Du, Yuguo.(2013).Substituent contribution to the genotoxicity of benzophenone-type UV filters.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,95(1),241-246.
MLA	Zhao, Huimin,et al."Substituent contribution to the genotoxicity of benzophenone-type UV filters".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 95.1(2013):241-246.