Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus
	Zhou, Wen-Bing 1,2; Zeng, Guang-Zhi 1; Xu, Hui-Min 1,2; He, Wen-Jun 1; Zhang, Yu-Mei 1; Tan, Ning-Hua 1
刊名	FITOTERAPIA
	2014-03-01
卷号	93 页码:98-104
关键词	Aster tataricus Shionane-type triterpenes Astershionones A-F Anti-HBV
ISSN号	0367-326X
通讯作者	Tan, NH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West C, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China. ; nhtan@mail.kib.ac.cn
英文摘要	Six new shionane-type triterpenes, astershionones A-F (1-6), were obtained from the roots and rhizomes of Aster tataricus. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configuration of 1 was determined by single crystal X-ray diffraction analysis and CD analysis. 3 showed inhibitory activity against HBsAg and HBeAg secretion with IC50 values of 23.0 and 23.1 mu M, and cytotoxicity against HepG 2.2.15 cells with a CC50 value of 170.5 mu M. 3 also exhibited inhibitory activity against HBV DNA replication with an IC50 value of 22.4 mu M (C) 2014 Elsevier B.V. All rights reserved.
学科主题	Chemistry, Medicinal ; Pharmacology & Pharmacy
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	ETUDE STRUCTURALE ; SHIONONE ; CYCLOPEPTIDE
收录类别	SCI
资助信息	National New Drug Innovation Major Project of China [2011ZX09307-002-02]; National Natural Science Foundation of China [U1032602, 91013002, 21102152]; Natural Science Foundation of Yunnan Province [2012GA003, 2011FZ206]; Foundation of Chinese Academy of Sciences (Hundred Talents Program)
语种	英语
WOS记录号	WOS:000333494500012
公开日期	2014-05-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18046]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West C, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Wen-Bing,Zeng, Guang-Zhi,Xu, Hui-Min,et al. Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus[J]. FITOTERAPIA,2014,93:98-104.
APA	Zhou, Wen-Bing,Zeng, Guang-Zhi,Xu, Hui-Min,He, Wen-Jun,Zhang, Yu-Mei,&Tan, Ning-Hua.(2014).Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus.FITOTERAPIA,93,98-104.
MLA	Zhou, Wen-Bing,et al."Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus".FITOTERAPIA 93(2014):98-104.