Hollow structured SrMoO4:Yb3+, Ln(3+) (Ln = Tm, Ho, Tm/Ho) microspheres: tunable up-conversion emissions and application as drug carriers

	Hollow structured SrMoO4:Yb3+, Ln(3+) (Ln = Tm, Ho, Tm/Ho) microspheres: tunable up-conversion emissions and application as drug carriers
	Wang Y ; Yang PP ; Ma PA ; Qu FY ; Gai SL ; Niu N ; He F ; Lin J
刊名	journal of materials chemistry b
	2013
卷号	1 期号:15 页码:2056-2065
关键词	MESOPOROUS SILICA NANOPARTICLES SOL-GEL PROCESS LUMINESCENCE PROPERTIES CONTROLLED-RELEASE DIFFERENT MORPHOLOGIES CAMOO4 NANOPARTICLES POLYMER CAPSULES DELIVERY SYSTEMS RED PHOSPHORS SHELL
ISSN号	2050-750x
通讯作者	wang y
中文摘要	in this study, a facile and mild one-pot approach was employed to prepare hollow-structured srmoo4 spheres using soluble sodium poly(4-styrenesulfonate) (pss) as a soft template. it is found that the as-prepared product exhibits hollow spherical morphology, good dispersity, and narrow size distribution. the formation mechanism has also been proposed. tunable multicolor and bright white up-conversion (uc) emissions were successfully realized by precisely adjusting the doping sensitizer (yb3+) and activator (tm3+, ho3+, and tm3+/ho3+) concentration in the host matrix. mtt assay shows the good biocompatibility of srmoo4:yb3+/tm3+ hollow spheres, which were used as an anti-cancer drug carrier to evaluate the loading and controlled release behavior by selecting doxorubicin hydrochloride (dox) as a model drug. drug release tests reveal a sustained drug release behavior and especially the uc emission intensities of the drug loaded system increase with the released amount of dox, indicating that the extent of drug release can be monitored or tracked by the change in emission intensity. moreover, the in vitro cytotoxic effect against skov3 ovarian cancer cells of the dox-loaded carrier was investigated and the endocytosis process of drug-loaded microspheres was studied using confocal laser scanning microscopy (clsm) and flow cytometry. considering the good biocompatibility, high drug loading amount and obvious sustained drug release properties, the hollow microspheres are highly promising in biological areas.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000316574100009
公开日期	2014-04-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50340]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang Y,Yang PP,Ma PA,et al. Hollow structured SrMoO4:Yb3+, Ln(3+) (Ln = Tm, Ho, Tm/Ho) microspheres: tunable up-conversion emissions and application as drug carriers[J]. journal of materials chemistry b,2013,1(15):2056-2065.
APA	Wang Y.,Yang PP.,Ma PA.,Qu FY.,Gai SL.,...&Lin J.(2013).Hollow structured SrMoO4:Yb3+, Ln(3+) (Ln = Tm, Ho, Tm/Ho) microspheres: tunable up-conversion emissions and application as drug carriers.journal of materials chemistry b,1(15),2056-2065.
MLA	Wang Y,et al."Hollow structured SrMoO4:Yb3+, Ln(3+) (Ln = Tm, Ho, Tm/Ho) microspheres: tunable up-conversion emissions and application as drug carriers".journal of materials chemistry b 1.15(2013):2056-2065.