Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry

	Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry
	Cheng YL ; He CL ; Xiao CS ; Ding JX ; Ren KX ; Yu SJ ; Zhuang XL ; Chen XS
刊名	polymer chemistry
	2013
卷号	4 期号:13 页码:3851-3858
关键词	INTRACELLULAR DRUG-DELIVERY SUPRAMOLECULAR ASSEMBLIES POLY(L-GLUTAMIC ACID) BLOCK-COPOLYMERS PH NANOPARTICLES DOXORUBICIN RELEASE NANOGEL THERAPEUTICS
ISSN号	1759-9954
通讯作者	chen xs
中文摘要	this study aims to develop novel reduction-responsive cross-linked micelles (cms) based on poly(ethylene glycol)-block-poly(gamma-propargyl-l-glutamate) (peg-pplg) by click chemistry. h-1 nmr spectroscopy, ir spectroscopy, dynamic light scattering (dls) and transmission electron microscopy (tem) were performed to confirm the successful construction of the cms. doxorubicin (dox) was loaded into the cms as a model anticancer drug. the dox-loaded cms could hold the drug under physiological conditions, and release the payload quickly in the presence of glutathione (gsh). confocal laser scanning microscopy (clsm) and flow cytometry measurements revealed that the intracellular drug release from the dox-loaded cms was increased in the hela cells with an enhanced intracellular gsh level. in vitro methyl thiazolyl tetrazolium (mtt) assays indicated that the cms were biocompatible, and dox-loaded cms showed higher cellular proliferation inhibition towards gsh-pretreated hela cells than non-pretreated cells. due to their unique responsiveness, the biocompatible cms show promise for the intracellular delivery of chemotherapeutic drugs in cancer therapy.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000319887700025
公开日期	2014-04-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50272]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Cheng YL,He CL,Xiao CS,et al. Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry[J]. polymer chemistry,2013,4(13):3851-3858.
APA	Cheng YL.,He CL.,Xiao CS.,Ding JX.,Ren KX.,...&Chen XS.(2013).Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry.polymer chemistry,4(13),3851-3858.
MLA	Cheng YL,et al."Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry".polymer chemistry 4.13(2013):3851-3858.