G-Quadruplexes Form Ultrastable Parallel Structures in Deep Eutectic Solvent

	G-Quadruplexes Form Ultrastable Parallel Structures in Deep Eutectic Solvent
	Zhao CQ ; Ren JS ; Qu XG
刊名	langmuir
	2013
卷号	29 期号:4 页码:1183-1191
关键词	TELOMERIC G-QUADRUPLEX INTRAMOLECULAR G-QUADRUPLEX IONIC LIQUIDS K+ SOLUTION CARBOXYLIC-ACIDS HIV-1 INTEGRASE DNA QUADRUPLEX NUCLEIC-ACIDS SEQUENCE HYDRATION
ISSN号	0743-7463
通讯作者	qu xg
中文摘要	g-quadruplex dna is highly polymorphic. its conformation transition is involved in a series of important life events. these controllable diverse structures also make g-quadruplex dna a promising candidate as catalyst, biosensor, and dna-based architecture. so far, g-quadruplex dna-based applications are restricted done in aqueous media. since many chemical reactions and devices are required to be performed under strictly anhydrous conditions, even at high temperature, it is challenging and meaningful to conduct g-quadruplex dna in water-free medium. in this report, we systemically studied 10 representative g-quadruplexes in anhydrous room-temperature deep eutectic solvents (dess). the results indicate that intramolecular, intermolecular, and even higher-order g-quadruplex structures can be formed in des. intriguingly, in des, parallel structure becomes the g-quadruplex dna preferred conformation. more importantly, compared to aqueous media, g-quadruplex has ultrastability in des and, surprisingly, some g-quadruplex dna can survive even beyond 110 degrees c. our work would shed light on the applications of g-quadruplex dna to chemical reactions and dna-based devices performed in an anhydrous environment, even at high temperature.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000314391300025
公开日期	2014-04-16
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50085]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhao CQ,Ren JS,Qu XG. G-Quadruplexes Form Ultrastable Parallel Structures in Deep Eutectic Solvent[J]. langmuir,2013,29(4):1183-1191.
APA	Zhao CQ,Ren JS,&Qu XG.(2013).G-Quadruplexes Form Ultrastable Parallel Structures in Deep Eutectic Solvent.langmuir,29(4),1183-1191.
MLA	Zhao CQ,et al."G-Quadruplexes Form Ultrastable Parallel Structures in Deep Eutectic Solvent".langmuir 29.4(2013):1183-1191.