Surface modification of graphene nanopores for protein translocation

	Surface modification of graphene nanopores for protein translocation
	Shan YP ; Tiwari PB ; Krishnakumar P ; Vlassiouk I ; Li WZ ; Wang XW ; Darici Y ; Lindsay SM ; Wang HD ; Smirnov S ; He J
刊名	nanotechnology
	2013
卷号	24 期号:49 页码:文献号：495102
关键词	SOLID-STATE NANOPORES DNA TRANSLOCATION SINGLE TRANSPORT MOLECULES SENSORS
ISSN号	0957-4484
通讯作者	shan yp
中文摘要	studies of dna translocation through graphene nanopores have revealed their potential for dna sequencing. here we report a study of protein translocation through chemically modified graphene nanopores. a transmission electron microscope (tem) was used to cut nanopores with diameters between 5 and 20 nm in multilayer graphene prepared by chemical vapor deposition (cvd). after oxygen plasma treatment, the dependence of the measured ionic current on salt concentration and ph was consistent with a small surface charge induced by the formation of carboxyl groups. while translocation of gold nanoparticles (10 nm) was readily detected through such treated pores of a larger diameter, translocation of the protein ferritin was not observed either for oxygen plasma treated pores, or for pores modified with mercaptohexadecanoic acid. ferritin translocation events were reliably observed after the pores were modified with the phospholipid-peg (dppe-peg750) amphiphile. the ion current signature of translocation events was complex, suggesting that a series of interactions between the protein and pores occurs during the process.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000328215300002
公开日期	2014-04-14
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49398]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Shan YP,Tiwari PB,Krishnakumar P,et al. Surface modification of graphene nanopores for protein translocation[J]. nanotechnology,2013,24(49):文献号：495102.
APA	Shan YP.,Tiwari PB.,Krishnakumar P.,Vlassiouk I.,Li WZ.,...&He J.(2013).Surface modification of graphene nanopores for protein translocation.nanotechnology,24(49),文献号：495102.
MLA	Shan YP,et al."Surface modification of graphene nanopores for protein translocation".nanotechnology 24.49(2013):文献号：495102.