(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3
	Yan, Yong-Ming 1,4; Ai, Jun 3; Shi, Yan-Ni 1,4; Zuo, Zhi-Li1 ; Hou, Bo 1; Luo, Jie 1; Cheng, Yong-Xian 1,2
刊名	ORGANIC LETTERS
	2014-01-17
卷号	16 期号:2 页码:532-535
关键词	DISEASE PRODUCTS
ISSN号	1523-7060
通讯作者	Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,132 Lanhei Rd,Kunming 650201,Peoples R China. ; yxcheng@mail.kib.ac.cn
英文摘要	(+/-)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and a pair of NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures of compounds 1 and 2 were assigned using spectroscopic methods. Compound 1 was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-beta 1 (TGF-beta 1) induced rat renal proximal tubular cells and suppressed extracellular matrix expression in mesangial cells under diabetic conditions.
学科主题	Chemistry, Organic
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	DISEASE ; PRODUCTS
收录类别	SCI ; IC
资助信息	National Natural Science Foundation of China [21272241, 21172223]; Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources
语种	英语
WOS记录号	WOS:000330098400053
公开日期	2014-04-09
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17944]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China 3.Southern Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yan, Yong-Ming,Ai, Jun,Shi, Yan-Ni,et al. (+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3[J]. ORGANIC LETTERS,2014,16(2):532-535.
APA	Yan, Yong-Ming.,Ai, Jun.,Shi, Yan-Ni.,Zuo, Zhi-Li.,Hou, Bo.,...&Cheng, Yong-Xian.(2014).(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3.ORGANIC LETTERS,16(2),532-535.
MLA	Yan, Yong-Ming,et al."(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3".ORGANIC LETTERS 16.2(2014):532-535.