Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx
	Wang, Wei-Guang 1,2; Li, Xiao-Nian 1; Du, Xue 1; Wu, Hai-Yan 1; Liu, Xu 1; Su, Jia 1; Li, Yan1 ; Pu, Jian-Xin1 ; Sun, Han-Dong1
刊名	JOURNAL OF NATURAL PRODUCTS
	2012-06-01
卷号	75 期号:6 页码:1102-1107
关键词	ENT-KAURANE DITERPENOIDS VAR. LAXIFLORA LEUKEMIC-CELLS CYTOTOXICITY INDUCTION DIFFERENTIATION ANTIOXIDANT MACROPHAGES PRODUCTS PHARICIN
ISSN号	0163-3864
通讯作者	Pu, JX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China,pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn
英文摘要	Laxiflorolides A (1) and B (2), two unprecedented epimeric bishomoditerpene lactones with a unique C-22 framework, along with laxiflorins P-R (3-5), maoecrystal P (6), maoecrystal C (7), and eriocalyxin B (8), were isolated from the leaves of I. eriocalyx var. laxiflora. The structures of 1 and 2, including the absolute configurations, were determined by spectroscopic methods and single-crystal X-ray diffraction analysis. All of the compounds isolated were evaluated for their cytotoxicity against five tumor cell lines. Compounds 3, 6, and 8 showed remarkable cytotoxic activity against certain cell lines compared with the positive control.
学科主题	Plant Sciences ; Pharmacology & Pharmacy
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	ENT-KAURANE DITERPENOIDS ; VAR. LAXIFLORA ; LEUKEMIC-CELLS ; CYTOTOXICITY ; INDUCTION ; DIFFERENTIATION ; ANTIOXIDANT ; MACROPHAGES ; PRODUCTS ; PHARICIN
收录类别	SCI ; IC
资助信息	The authors are grateful to Prof. X.-W. Li of the Kunming Institute of Botany, Chinese Academy of Sciences, for the identification of the plant. This project was supported financially by the NSFC-Joint Foundation of Yunnan Province (No. U0832602 to H.-D.S.), the National Natural Science Foundation of China (No. 81172939 to J.-X.P.), the Major State Basic Research Development Program of China (No. 2009CB522300), the Reservation-Talent Project of Yunnan Province (2011CI043 to J.-X.P.), the Science and Technology Program of Yunnan Province (No. 2008IF010), and the Major Direction Projection Foundation of CAS intellectual Innovation Project (No. KSCX2-EW-J-24 to J.-X.P.).
语种	英语
WOS记录号	WOS:000305503500014
公开日期	2014-04-02
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17607]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wei-Guang,Li, Xiao-Nian,Du, Xue,et al. Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(6):1102-1107.
APA	Wang, Wei-Guang.,Li, Xiao-Nian.,Du, Xue.,Wu, Hai-Yan.,Liu, Xu.,...&Sun, Han-Dong.(2012).Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx.JOURNAL OF NATURAL PRODUCTS,75(6),1102-1107.
MLA	Wang, Wei-Guang,et al."Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx".JOURNAL OF NATURAL PRODUCTS 75.6(2012):1102-1107.