Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation
	Yan, Yong-Ming 1,2; Wu, Gui-Sheng1 ; Dong, Xiao-Ping 2; Shen, Lan 1; Li, Yan1 ; Su, Jia 1; Luo, Huai-Rong1 ; Zhu, Hua-Jie 1; Cheng, Yong-Xian 1,2
刊名	JOURNAL OF NATURAL PRODUCTS
	2012-06-01
卷号	75 期号:6 页码:1025-1029
关键词	ELECTRONIC CIRCULAR-DICHROISM OPTICAL-ROTATION CHEMISTRY ASSAY
ISSN号	0163-3864
通讯作者	Zhu, HJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China,hjzhu@mail.kib.ac.cn ; yxcheng@mail.kib.ac.cn
英文摘要	Diincarvilones A-D (1-4), incarvilone A (5), and a known compound, argutosine B (6), were isolated from Incarvillea arguia. The structures, including the absolute configurations of the new compounds, were determined by NMR spectroscopy, X-ray diffraction analysis, CD spectroscopy, and a variety of computational methods. The biological properties of these substances, including effects on intracellular Ca2+ influx, nitric oxide (NO) production, and human cancer cells, were evaluated. The results showed that at the concentration of 10 mu M (in HBSS buffer) diincarvilones A and B cause a persistent increase in cytoplasmic calcium levels in A549 cells.
学科主题	Plant Sciences ; Pharmacology & Pharmacy
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	ELECTRONIC CIRCULAR-DICHROISM ; OPTICAL-ROTATION ; CHEMISTRY ; ASSAY
收录类别	SCI ; IC
资助信息	This work was financially supported by the Open Research Fund of the State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources and grants of the Top Talent Recruitment Program of Yunnan Province (2009C1120 and 20080A007) and 973 Program (2009CB522300).
语种	英语
WOS记录号	WOS:000305503500003
公开日期	2014-04-02
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17604]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
推荐引用方式 GB/T 7714	Yan, Yong-Ming,Wu, Gui-Sheng,Dong, Xiao-Ping,et al. Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(6):1025-1029.
APA	Yan, Yong-Ming.,Wu, Gui-Sheng.,Dong, Xiao-Ping.,Shen, Lan.,Li, Yan.,...&Cheng, Yong-Xian.(2012).Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation.JOURNAL OF NATURAL PRODUCTS,75(6),1025-1029.
MLA	Yan, Yong-Ming,et al."Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation".JOURNAL OF NATURAL PRODUCTS 75.6(2012):1025-1029.