Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity
	Zou, Juan 1,2; Jiang, Jing 3; Diao, Yan-Yan 3; Yang, Li-Bin 1; Huang, Jin 3; Li, Hong-Lin 3; Du, Xue 1; Xiao, Wei-Lie 1; Pu, Jian-Xin1 ; Sun, Han-Dong1
刊名	FITOTERAPIA
	2012-07-01
卷号	83 期号:5 页码:926-931
关键词	Schisandra glaucescens Schisandraceae Cycloartane triterpenoid FXR agonistic and antagonistic effects
ISSN号	0367-326X
通讯作者	Xiao, WL (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China,xwl@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn
英文摘要	Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC50 of 1.50 mu M. (C) 2012 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	ESTROGEN-RECEPTOR BETA ; NIGRANOIC ACID ; DISCOVERY ; LIGANDS
收录类别	SCI
资助信息	This project was supported financially by the NSFC (nos. 20802082 and 30830115), the projects from the Chinese Academy of Sciences (KSCX2-EW-Q-10 and KSCX1-YW-R-24), the Major State Basic Research Development Program of China (no. 2009CB522303 and 2009CB940900), the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (awarded to Dr. Hong-Lin Li), and the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q).
语种	英语
WOS记录号	WOS:000305657900018
公开日期	2014-04-02
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17600]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
推荐引用方式 GB/T 7714	Zou, Juan,Jiang, Jing,Diao, Yan-Yan,et al. Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity[J]. FITOTERAPIA,2012,83(5):926-931.
APA	Zou, Juan.,Jiang, Jing.,Diao, Yan-Yan.,Yang, Li-Bin.,Huang, Jin.,...&Sun, Han-Dong.(2012).Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity.FITOTERAPIA,83(5),926-931.
MLA	Zou, Juan,et al."Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity".FITOTERAPIA 83.5(2012):926-931.