Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment

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	Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment
	Wang, YC ; Black, KCL ; Luehmann, H ; Li, WY ; Zhang, Y ; Cai, X ; Wan, DH ; Liu, SY ; Li, M ; Kim, P ; Li, ZY ; Wang, LHV ; Liu, YJ ; Xia, YA
刊名	ACS NANO
	2013
卷号	7 期号:3 页码:2068
关键词	theranostics gold nanostructures near-infrared photothermal effect tumor ablation
ISSN号	1936-0851
通讯作者	Liu, YJ (reprint author), Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA.
中文摘要	Gold nanohexapods represent a novel class of optically tunable nanostructures consisting of an octahedral core and six arms grown on its vertices. By controlling the length of the arms, their localized surface plasmon resonance peaks could be tuned from the visible to the near-Infrared region for deep penetration of light Into soft tissues. Herein we compare the in vitro and In vivo capabilities of Au nanohexapods as photothermal transducers for theranostic applications by benchmarking against those of Au nanorods and nanocages. While all these Au nanostructures could absorb and convert near-infrared light into heat, Au nanohexapods exhibited the highest cellular uptake and the lowest cytotoxicity in vitro for both the as-prepared and PEGylated nanostructures. In vivo pharmacokinetic studies showed that the PEGylated Au nanohexapods had significant blood circulation and tumor accumulation in a mouse breast cancer model. Following photothermal treatment, substantial heat was produced in situ and the tumor metabolism was greatly reduced for all these Au nanostructures, as determined with F-18-flourodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT). Combined together, we can conclude that Au nanohexapods are promising candidates for cancer theranostics in terms of both photothermal destruction and contrast-enhanced diagnosis.
资助信息	NCI [R01 CA138527]; NSF NNIN program
语种	英语
公开日期	2014-01-16
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/56828]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Wang, YC,Black, KCL,Luehmann, H,et al. Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment[J]. ACS NANO,2013,7(3):2068.
APA	Wang, YC.,Black, KCL.,Luehmann, H.,Li, WY.,Zhang, Y.,...&Xia, YA.(2013).Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment.ACS NANO,7(3),2068.
MLA	Wang, YC,et al."Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment".ACS NANO 7.3(2013):2068.