Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family

CORC > 水生生物研究所 > 鱼类生物学及渔业生物技术研究中心 > 期刊论文

	Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family
	Liu, Ying; Zhang, Yi-Bing; Liu, Ting-Kai; Gui, Jian-Fang
刊名	PLOS ONE
	2013-06-20
卷号	8 期号:6 页码:e66859
关键词	INTERFERON-STIMULATED GENES DOUBLE-STRANDED-RNA DEPENDENT PROTEIN-KINASE INNATE IMMUNE-RESPONSE CARP CARASSIUS-AURATUS ANTIVIRAL RESPONSE INDUCIBLE PROTEIN MESSENGER-RNA I IFNS FISH
ISSN号	1932-6203
通讯作者	Zhang, YB (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China.
中文摘要	In mammals, IFIT (Interferon [IFN]-induced proteins with Tetratricopeptide Repeat [TPR] motifs) family genes are involved in many cellular and viral processes, which are tightly related to mammalian IFN response. However, little is known about non-mammalian IFIT genes. In the present study, IFIT genes are identified in the genome databases from the jawed vertebrates including the cartilaginous elephant shark but not from non-vertebrates such as lancelet, sea squirt and acorn worm, suggesting that IFIT gene family originates from a vertebrate ancestor about 450 million years ago. IFIT family genes show conserved gene structure and gene arrangements. Phylogenetic analyses reveal that this gene family has expanded through lineage-specific and species-specific gene duplication. Interestingly, IFN gene family seem to share a common ancestor and a similar evolutionary mechanism; the function link of IFIT genes to IFN response is present early since the origin of both gene families, as evidenced by the finding that zebrafish IFIT genes are upregulated by fish IFNs, poly(I:C) and two transcription factors IRF3/IRF7, likely via the IFN-stimulated response elements (ISRE) within the promoters of vertebrate IFIT family genes. These coevolution features creates functional association of both family genes to fulfill a common biological process, which is likely selected by viral infection during evolution of vertebrates. Our results are helpful for understanding of evolution of vertebrate IFN system.
英文摘要	In mammals, IFIT (Interferon [IFN]-induced proteins with Tetratricopeptide Repeat [TPR] motifs) family genes are involved in many cellular and viral processes, which are tightly related to mammalian IFN response. However, little is known about non-mammalian IFIT genes. In the present study, IFIT genes are identified in the genome databases from the jawed vertebrates including the cartilaginous elephant shark but not from non-vertebrates such as lancelet, sea squirt and acorn worm, suggesting that IFIT gene family originates from a vertebrate ancestor about 450 million years ago. IFIT family genes show conserved gene structure and gene arrangements. Phylogenetic analyses reveal that this gene family has expanded through lineage-specific and species-specific gene duplication. Interestingly, IFN gene family seem to share a common ancestor and a similar evolutionary mechanism; the function link of IFIT genes to IFN response is present early since the origin of both gene families, as evidenced by the finding that zebrafish IFIT genes are upregulated by fish IFNs, poly(I:C) and two transcription factors IRF3/IRF7, likely via the IFN-stimulated response elements (ISRE) within the promoters of vertebrate IFIT family genes. These coevolution features creates functional association of both family genes to fulfill a common biological process, which is likely selected by viral infection during evolution of vertebrates. Our results are helpful for understanding of evolution of vertebrate IFN system.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	INTERFERON-STIMULATED GENES ; DOUBLE-STRANDED-RNA ; DEPENDENT PROTEIN-KINASE ; INNATE IMMUNE-RESPONSE ; CARP CARASSIUS-AURATUS ; ANTIVIRAL RESPONSE ; INDUCIBLE PROTEIN ; MESSENGER-RNA ; I IFNS ; FISH
收录类别	SCI
资助信息	973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31272690, 31172435]
语种	英语
WOS记录号	WOS:000322342800106
公开日期	2014-01-06
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/19583]
专题	水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
作者单位	Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ying,Zhang, Yi-Bing,Liu, Ting-Kai,et al. Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family[J]. PLOS ONE,2013,8(6):e66859.
APA	Liu, Ying,Zhang, Yi-Bing,Liu, Ting-Kai,&Gui, Jian-Fang.(2013).Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family.PLOS ONE,8(6),e66859.
MLA	Liu, Ying,et al."Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family".PLOS ONE 8.6(2013):e66859.