Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation

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	Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation
	Liu, Rui 1,2; Sun, Wei 3; Liu, Chun-Zhao 1,2
刊名	BIOTECHNOLOGY PROGRESS
	2011-11-01
卷号	27 期号:6 页码:1661-1671
关键词	computational fluid dynamics multiphase flow hydrodynamics mass transfer hairy root
ISSN号	8756-7938
其他题名	Biotechnol. Prog.
中文摘要	A two-dimensional axisymmetric computational fluid dynamics (CFD) model based on a porous media model and a discrete population balance model was established to investigate the hydrodynamics and mass transfer behavior in an airlift bioreactor for hairy root culture. During the hairy root culture of Echinacea purpurea, liquid and gas velocity, gas holdup, mass transfer rate, as well as oxygen concentration distribution in the airlift bioreactor were simulated by this CFD model. Simulative results indicated that liquid flow and turbulence played a dominant role in oxygen mass transfer in the growth domain of the hairy root culture. The dissolved oxygen concentration in the hairy root clump increased from the bottom to the top of the bioreactor cultured with the hairy roots, which was verified by the experimental detection of dissolved oxygen concentration in the hairy root clump. This methodology provided insight understanding on the complex system of hairy root culture and will help to eventually guide the bioreactor design and process intensification of large-scale hairy root culture. (C) 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
英文摘要	A two-dimensional axisymmetric computational fluid dynamics (CFD) model based on a porous media model and a discrete population balance model was established to investigate the hydrodynamics and mass transfer behavior in an airlift bioreactor for hairy root culture. During the hairy root culture of Echinacea purpurea, liquid and gas velocity, gas holdup, mass transfer rate, as well as oxygen concentration distribution in the airlift bioreactor were simulated by this CFD model. Simulative results indicated that liquid flow and turbulence played a dominant role in oxygen mass transfer in the growth domain of the hairy root culture. The dissolved oxygen concentration in the hairy root clump increased from the bottom to the top of the bioreactor cultured with the hairy roots, which was verified by the experimental detection of dissolved oxygen concentration in the hairy root clump. This methodology provided insight understanding on the complex system of hairy root culture and will help to eventually guide the bioreactor design and process intensification of large-scale hairy root culture. (C) 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biotechnology & Applied Microbiology ; Food Science & Technology
研究领域[WOS]	Biotechnology & Applied Microbiology ; Food Science & Technology
关键词[WOS]	OXYGEN REQUIREMENTS ; AIRLIFT REACTOR ; FLOW ; HYDRODYNAMICS ; SCAFFOLDS ; TRANSPORT ; DESIGN ; GROWTH ; BUBBLE
收录类别	SCI
原文出处	://WOS:000297551300017
语种	英语
WOS记录号	WOS:000297551300017
公开日期	2013-11-28
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/6287]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Gen Hosp AF, Dept Informat, Beijing 100142, Peoples R China
推荐引用方式 GB/T 7714	Liu, Rui,Sun, Wei,Liu, Chun-Zhao. Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation[J]. BIOTECHNOLOGY PROGRESS,2011,27(6):1661-1671.
APA	Liu, Rui,Sun, Wei,&Liu, Chun-Zhao.(2011).Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation.BIOTECHNOLOGY PROGRESS,27(6),1661-1671.
MLA	Liu, Rui,et al."Computational fluid dynamics modeling of mass transfer behavior in a bioreactor for hairy root culture. I. Model development and experimental validation".BIOTECHNOLOGY PROGRESS 27.6(2011):1661-1671.