Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway

doi:10.1016/j.colsurfb.2023.113656

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	Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway
	Dong, Kehong 1; Sun, Yuxuan 1; Gao, Xintao 1; Wang, Jing 2; Wu, Xiaochen 1; Guo, Chuanlong 1,3
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2024
卷号	233 页码:12
关键词	Acetaminophen Liver injury Hesperidin MtDNA CGAS-STING
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2023.113656
通讯作者	Guo, Chuanlong(guochuanlong@qust.edu.cn)
英文摘要	Excessive acetaminophen (APAP) is the main cause of drug-induced acute liver failure, and the pathogenesis has not been elucidated and there is a lack of effective drugs. Hesperidin (Hes), a rich flavanone in citrus peel with excellent biological activities, is a potential agent for treatment liver injury. Due to poor water solubility of Hes, this study prepared mixed micelles using polyvinyl pyrrolidone (PVP K17) and poloxamer 188, and encapsulated Hes (Hes-MMs). The results showed that Hes-MMs exhibited a uniform spherical shape with a particle size of 66.80 +/- 0.83 nm, and Hes-MMs significantly improved the dispersibility, antioxidant activity, and cellular up -take of Hes. In vitro results showed that Hes-MMs protected the proliferation inhibition of HepG2 cells induced by APAP, inhibited the production of reactive oxygen species (ROS) and the damage of mitochondrial membrane potential (MMP) induced by APAP. Furthermore, Hes-MMs exerted liver protective effects by inhibiting APAP induced mtDNA release and activating the cGAS-STING pathway. In vivo results demonstrated that Hes-MMs showed protective and therapeutic effects on APAP induced liver injury, and their mechanisms were related to the mtDNA-cGAS-STING signaling pathway. In summary, our study demonstrated that the mtDNA-cGAS-STING pathway was involved in APAP induced acute liver injury, and Hes-MMs might be a potential therapeutic agent for treating APAP induced acute liver injury.
资助项目	Shandong Provincial Natural Science Foundation[ZR2020QH359] ; Open Fund of CAS ; Open Fund of CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences[KF2022NO06] ; Program for Young Talents of Science and Technology in Universities of Inner Mongolia[NJYT-18-B29] ; Doctoral Scientific Research Foundation of Inner Mongolia[BTTCRCQD2018001]
WOS关键词	DRUG-DELIVERY ; IN-VIVO ; MITOCHONDRIAL ; HEPATOTOXICITY ; ATTENUATION ; ABSORPTION ; HESPERETIN ; STRESS ; CANCER
WOS研究方向	Biophysics ; Chemistry ; Materials Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:001119630400001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/184131]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Guo, Chuanlong
作者单位	1.Qingdao Univ Sci & Technol, Coll Chem Engn, Dept Pharm, Qingdao 266042, Peoples R China 2.Baotou Teachers Coll, Dept Biol Sci & Technol, Baotou 014030, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Dong, Kehong,Sun, Yuxuan,Gao, Xintao,et al. Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2024,233:12.
APA	Dong, Kehong,Sun, Yuxuan,Gao, Xintao,Wang, Jing,Wu, Xiaochen,&Guo, Chuanlong.(2024).Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway.COLLOIDS AND SURFACES B-BIOINTERFACES,233,12.
MLA	Dong, Kehong,et al."Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway".COLLOIDS AND SURFACES B-BIOINTERFACES 233(2024):12.