Hierarchical rhythmic propagation of corticothalamic interactions for consciousness: A computational study

doi:10.1016/j.compbiomed.2023.107843

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	Hierarchical rhythmic propagation of corticothalamic interactions for consciousness: A computational study
	Zhang, Qian 1,3; Lu, Han 2; Wang, Jihang 1,3; Yang, Taoyi 1; Bi, Weida 1; Zeng, Yi 1,3,4; Yu, Buwei 2
刊名	COMPUTERS IN BIOLOGY AND MEDICINE
	2024-02-01
卷号	169 页码:10
关键词	Corticothalamic model Spiking neural network Consciousness General anesthesia Anteriorization
ISSN号	0010-4825
DOI	10.1016/j.compbiomed.2023.107843
通讯作者	Zeng, Yi(yi.zeng@ia.ac.cn) ; Yu, Buwei(yubuwei_2013@126.com)
英文摘要	Clarifying the mechanisms of loss and recovery of consciousness in the brain is a major challenge in neuroscience, and research on the spatiotemporal organization of rhythms at the brain region scale at different levels of consciousness remains scarce. By applying computational neuroscience, an extended corticothalamic network model was developed in this study to simulate the altered states of consciousness induced by different concentration levels of propofol. The cortex area containing oscillation spread from posterior to anterior in four successive time stages, defining four groups of brain regions. A quantitative analysis showed that hierarchical rhythm propagation was mainly due to heterogeneity in the inter-brain region connections. These results indicate that the proposed model is an anatomically data-driven testbed and a simulation platform with millisecond resolution. It facilitates understanding of activity coordination across multiple areas of the conscious brain and the mechanisms of action of anesthetics in terms of brain regions.
资助项目	Frontier Scientific Research Program of Chinese Academy of Sciences[ZDBS-LY-JSC013] ; National Natural Science Foundation of China[82271204] ; National Natural Science Foundation of China[81771138] ; Artificial Intelligence of General Anesthesia Mechanism Program of Yichang Human-well[Y8D1051LE1]
WOS关键词	TEMPORAL RECEPTIVE WINDOWS ; GENERAL-ANESTHESIA ; FIRING RATES ; BRAIN STATES ; MODEL ; OSCILLATION ; MECHANISMS ; NETWORKS ; TRACKING ; SPIKING
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Computer Science ; Engineering ; Mathematical & Computational Biology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:001142312500001
资助机构	Frontier Scientific Research Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; Artificial Intelligence of General Anesthesia Mechanism Program of Yichang Human-well
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/54810]
专题	脑图谱与类脑智能实验室
通讯作者	Zeng, Yi; Yu, Buwei
作者单位	1.Chinese Acad Sci, Inst Automat, Brain inspired Cognit Intelligence Lab, Beijing 100190, Peoples R China 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Anesthesiol, Sch Med, Shanghai 200025, Peoples R China 3.Univ Chinese Acad Sci, Sch Arti ficial Intelligence, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Qian,Lu, Han,Wang, Jihang,et al. Hierarchical rhythmic propagation of corticothalamic interactions for consciousness: A computational study[J]. COMPUTERS IN BIOLOGY AND MEDICINE,2024,169:10.
APA	Zhang, Qian.,Lu, Han.,Wang, Jihang.,Yang, Taoyi.,Bi, Weida.,...&Yu, Buwei.(2024).Hierarchical rhythmic propagation of corticothalamic interactions for consciousness: A computational study.COMPUTERS IN BIOLOGY AND MEDICINE,169,10.
MLA	Zhang, Qian,et al."Hierarchical rhythmic propagation of corticothalamic interactions for consciousness: A computational study".COMPUTERS IN BIOLOGY AND MEDICINE 169(2024):10.