深海冷泉草酸青霉Penicillium oxalicum 13-37的化学成分研究

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	深海冷泉草酸青霉Penicillium oxalicum 13-37的化学成分研究
	刘雅萍 1,2; 方圣涛 1; 时振振 1; 季乃云 1
刊名	海洋科学
	2022
卷号	46 期号:5 页码:115-121
关键词	深海冷泉草酸青霉次生代谢产物化学成分生物活性
ISSN号	1000-3096
其他题名	Chemical constituents of Penicillium oxalicum 13-37 from cold-seep sediments
文献子类	期刊论文
英文摘要	To enrich the structural diversity of natural products from a deep-sea cold seep, the secondary metabolites of Penicillium oxalicum 13-37, a fungus derived from cold-seep sediments, were investigated. Eleven compounds were obtained using silica gel column chromatography, reversed-phase silica gel column chromatography, Sephadex LH-20 gel column chromatography, preparative thin-layer chromatography, and semi-preparative high-performance liquid chromatography. They were identified as seco-blennolide B(1), blennolide B(2), citreorosein(3), emodine(4), isorhodoptilometrin(5), aloe-emodin(6), 2-acetylemodin(7), 11-O-acetylaloeemodin(8), phaseolorin I(9), penitholabene(10), and paecilomycine A(11). Among them, 1 is a novel compound. Compounds 10 and 11 are known terpenoids isolated from cold seep-derived Penicillium oxalicum for the first time, and the single-crystal data of compound 10 are reported for the first time. Additionally, the activities of the new compound were tested. The results revealed that the new compound has inhibitory effects on the growth of Prorocentrum donghaiense, Chattonella marina, and Vibrio parahaemolyticus. Furthermore, compound 1 weakly inhibited Artemia salina.
语种	中文
CSCD记录号	CSCD:7240764
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/34129]
专题	海岸带生物学与生物资源利用重点实验室
作者单位	1.中国科学院烟台海岸带研究所,山东烟台264003; 2.中国科学院大学,北京100049
推荐引用方式 GB/T 7714	刘雅萍,方圣涛,时振振,等. 深海冷泉草酸青霉Penicillium oxalicum 13-37的化学成分研究[J]. 海洋科学,2022,46(5):115-121.
APA	刘雅萍,方圣涛,时振振,&季乃云.(2022).深海冷泉草酸青霉Penicillium oxalicum 13-37的化学成分研究.海洋科学,46(5),115-121.
MLA	刘雅萍,et al."深海冷泉草酸青霉Penicillium oxalicum 13-37的化学成分研究".海洋科学 46.5(2022):115-121.