Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of & alpha;-tocopherol

doi:10.1016/j.foodchem.2023.136886

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of & alpha;-tocopherol
	Yuan, Yuting 1,2,5; Wang, Zhenhua 3; Su, Shengjia 4; Lin, Conghao 3; Mi, Yingqi 1,2; Tan, Wenqiang 1,2; Guo, Zhanyong 1,2,5
刊名	FOOD CHEMISTRY
	2023-12-15
卷号	429 页码:11
关键词	Amphiphilic low molecular weight chitosan derivative Photostability Self-assembled cationic micelle Solubility Sustained release behavior & alpha -tocopherol
ISSN号	0308-8146
DOI	10.1016/j.foodchem.2023.136886
通讯作者	Tan, Wenqiang(wqtan@yic.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	New amphiphilic low molecular weight chitosan-graft-nicotinic acid bearing decyl groups (LCND) was synthesized by two-step reaction and spontaneously assembled into cationic micelle by ultra-sonication method to improve water solubility and photostability properties of a-tocopherol. The chemical structure of LCND was characterized and physical properties of cationic micelle were evaluated. Results displayed that cationic micelle exhibited strong self-assemble ability with nanoscale spherical morphology and showed best loading ability with loading content of 18.50% when the feeding ratio of LCND to a-tocopherol reached 10:3. Meanwhile, the greatly enhanced water solubility, photostability and sustained release behavior of a-tocopherol in cationic micelle were observed. The cumulative release of a-tocopherol in cationic micelle reached up 82.18% within 96 h while free a-tocopherol was completely released within 10 h. Additionally, release kinetics models were also fitted. The LCND cationic micelle could be promising nanocarrier for improving the physicochemical properties of a-tocopherol in food fields.
WOS关键词	ALPHA-TOCOPHEROL ; PHOTOSTABILITY ; NANOPARTICLES ; ENCAPSULATION ; DERIVATIVES ; DELIVERY
WOS研究方向	Chemistry ; Food Science & Technology ; Nutrition & Dietetics
语种	英语
WOS记录号	WOS:001050470800001
资助机构	Youth Innovation Promotion Association CAS, China ; Shandong Key Ramp;D plan, Major Scientific and Technological Innovation Project ; Science amp; Technology Specific Projects in Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/33450]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Tan, Wenqiang; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 3.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China 4.Shandong Saline Alkali Land Modern Agr Co, Dongying 257300, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Yuting,Wang, Zhenhua,Su, Shengjia,et al. Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of & alpha;-tocopherol[J]. FOOD CHEMISTRY,2023,429:11.
APA	Yuan, Yuting.,Wang, Zhenhua.,Su, Shengjia.,Lin, Conghao.,Mi, Yingqi.,...&Guo, Zhanyong.(2023).Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of & alpha;-tocopherol.FOOD CHEMISTRY,429,11.
MLA	Yuan, Yuting,et al."Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of & alpha;-tocopherol".FOOD CHEMISTRY 429(2023):11.