Potential Involvement of DNA Methylation in Hybrid Sterility in Hermaphroditic Argopecten Scallops

doi:10.1007/s10126-023-10233-4

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Potential Involvement of DNA Methylation in Hybrid Sterility in Hermaphroditic Argopecten Scallops
	Yu, Tieying 2,4; Ning, Junhao 4; Chen, Min 4; Wang, Fukai 3; Liu, Guilong 1; Wang, Quanchao 4; Xu, Xin 1; Wang, Chunde 2,3,4; Lu, Xia 4
刊名	MARINE BIOTECHNOLOGY
	2023-08-07
页码	17
关键词	Hermaphroditic Argopecten scallops Hybrid sterility DNA methylation Oogenesis ROS ATP
ISSN号	1436-2228
DOI	10.1007/s10126-023-10233-4
通讯作者	Lu, Xia(luxia_0202@163.com)
英文摘要	DNA methylation is an important epigenetic modification factor in regulating fertility. Corresponding process remains poorly investigated in hermaphroditic scallops. The interspecific F-1 hybrids between the hermaphroditic bay scallops (Argopecten irradians) and Peruvian scallops (Argopecten purpuratus) exhibited significant heterosis in yield, but sterility in hybrids obstructs the utilization of the genetic resources. However, the determination mechanism of hybrid sterility in the hermaphroditic Argopecten scallops is still unclear. In this study, the effect of DNA methylation in the hybrid sterility of hermaphroditic Argopecten scallops was explored. The results showed that the mean methylation level was higher in sterile hybrids than fertile hybrids, especially on chromosome 11 of the paternal parent. A total of 61,062 differentially methylated regions (DMRs) were identified, containing 3619 differentially methylated genes (DMGs) and 1165 differentially methylated promoters that are located in the DMRs of CG sequence context. The hyper-methylated genes were enriched into five KEGG pathways, including ubiquitin-mediated proteolysis, ECM-receptor interaction, non-homologous end-joining, notch signaling, and the mismatch repair pathways. The DMGs might induce hybrid sterility by inhibition of oogenesis and egg maturation, induction of apoptosis, increased ROS, and insufficient ATP supply. Our results would enrich the determination mechanism of hybrid sterility and provide new insights into the utilization of the genetic resources of the interspecific hybrids.
WOS关键词	MISMATCH REPAIR ; BAY SCALLOP ; CELL-GROWTH ; GENE ; EXPRESSION ; MUTATION ; PATHWAY ; IDENTIFICATION ; TRANSCRIPTOME ; ENDOMETRIUM
WOS研究方向	Biotechnology & Applied Microbiology ; Marine & Freshwater Biology
语种	英语
WOS记录号	WOS:001043652800001
资助机构	National Natural Science Foundation of China ; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province ; Scientific and Technological Project of Yantai, Shandong Province ; Earmarked Fund for Shandong Modern Agro-Industry Technology Research System ; Science and Technology Innovation Capacity Improvement Project in Shandong Province
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/33417]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Lu, Xia
作者单位	1.Yantai Spring Sea AquaSeed Ltd, Yantai 264006, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Yu, Tieying,Ning, Junhao,Chen, Min,et al. Potential Involvement of DNA Methylation in Hybrid Sterility in Hermaphroditic Argopecten Scallops[J]. MARINE BIOTECHNOLOGY,2023:17.
APA	Yu, Tieying.,Ning, Junhao.,Chen, Min.,Wang, Fukai.,Liu, Guilong.,...&Lu, Xia.(2023).Potential Involvement of DNA Methylation in Hybrid Sterility in Hermaphroditic Argopecten Scallops.MARINE BIOTECHNOLOGY,17.
MLA	Yu, Tieying,et al."Potential Involvement of DNA Methylation in Hybrid Sterility in Hermaphroditic Argopecten Scallops".MARINE BIOTECHNOLOGY (2023):17.