Advances in biosynthesis of peptide drugs: Technology and industrialization

doi:10.1002/biot.202300256

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Advances in biosynthesis of peptide drugs: Technology and industrialization
	Wang, Jing 1,2; Chen, Long 3; Qin, Song 1; Xie, Mingyuan 4; Luo, Shi-Zhong 3,5; Li, Wenjun 1,6
刊名	BIOTECHNOLOGY JOURNAL
	2023-11-14
页码	13
关键词	biosynthesis technology industrialization peptide drugs peptide synthesis
ISSN号	1860-6768
DOI	10.1002/biot.202300256
通讯作者	Luo, Shi-Zhong(luosz@mail.buct.edu.cn) ; Li, Wenjun(wjli@yic.ac.cn)
英文摘要	Peptide drugs are developed from endogenous or synthetic peptides with specific biological activities. They have advantages of strong target specificity, high efficacy and low toxicity, thus showing great promise in the treatment of many diseases such as cancer, infections, and diabetes. Although an increasing number of peptide drugs have entered market in recent years, the preparation of peptide drug substances is yet a bottleneck problem for their industrial production. Comparing to the chemical synthesis method, peptide biosynthesis has advantages of simple synthesis, low cost, and low contamination. Therefore, the biosynthesis technology of peptide drugs has been widely used for manufacturing. Herein, we reviewed the development of peptide drugs and recent advances in peptide biosynthesis technology, in order to shed a light to the prospect of industrial production of peptide drugs based on biosynthesis technology. Peptide drugs are developed from endogenous or synthetic peptides with specific biological activities. Currently, with the development of biotechnology, the development and marketing of peptide drugs are showing a steady increasing trend. Recombinant peptide drugs have been widely used in medical applications such as diabetes, cancer, osteoporosis, multiple sclerosis, and hepatitis. Herein, we reviewed the development of peptide drugs and recent advances in peptide biosynthesis technology, in order to shed a light to the prospect of industrial production of peptide drugs based on biosynthesis technology.image
WOS关键词	HALF-LIFE ; INSULIN ; ALLOPHYCOCYANIN ; STABILITY ; SEQUENCE ; VACCINE ; DESIGN ; CANCER ; ENZYME ; LIGAND
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
语种	英语
WOS记录号	WOS:001101802300001
资助机构	This work was supported by The National Key Research and Development Program of China (2021YFC2103900), Special Plan for Major Scientific and Technological Innovation in Qingdao West Coast (Grant numbers: ZDKC-2022-04) and High tech industrialization spec ; National Key Research and Development Program of China ; , Special Plan for Major Scientific and Technological Innovation in Qingdao West Coast ; High tech industrialization special project in cooperation between Jilin Province ; Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/33225]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Luo, Shi-Zhong; Li, Wenjun
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Shandong, Peoples R China 2.Binzhou Med Univ, Coll Pharm, Yantai, Shandong, Peoples R China 3.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing, Peoples R China 4.Sun Yat Sen Univ, Sch Phys, State Key Lab Optoelect Mat & Technol, Guangzhou, Peoples R China 5.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China 6.Chinese Acad Sci, Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jing,Chen, Long,Qin, Song,et al. Advances in biosynthesis of peptide drugs: Technology and industrialization[J]. BIOTECHNOLOGY JOURNAL,2023:13.
APA	Wang, Jing,Chen, Long,Qin, Song,Xie, Mingyuan,Luo, Shi-Zhong,&Li, Wenjun.(2023).Advances in biosynthesis of peptide drugs: Technology and industrialization.BIOTECHNOLOGY JOURNAL,13.
MLA	Wang, Jing,et al."Advances in biosynthesis of peptide drugs: Technology and industrialization".BIOTECHNOLOGY JOURNAL (2023):13.