Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide

doi:10.1016/j.talanta.2023.125293

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide
	Zhang, Xia 3,4,5; Yang, Yang 5; Zhang, Li 3,5; Liu, Shudi 1; Song, Zhihua 6; Zhang, Liangwei 5; You, Jinmao 2; Chen, Lingxin 5
刊名	TALANTA
	2024-02-01
卷号	268 页码:8
关键词	New recognition moiety H2Sn Probe design Fluorescent probe Living cells imaging
ISSN号	0039-9140
DOI	10.1016/j.talanta.2023.125293
通讯作者	Zhang, Liangwei(liangweizhang@yic.ac.cn) ; You, Jinmao(jmyou6304@163.com) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	Hydrogen polysulfide (H2Sn, n > 1) is an important component of reactive sulfur species (RSS), which is an important substance for maintaining the redox balance in cells. However, limited recognition moieties are available for hydrogen polysulfide probe design. In this study, we have constructed a small library containing several organic molecules to explore a new specific recognition moiety for H2Sn fluorescent probe design. To validate the discovery, two fluorescent probes, 7 and BCC, were further developed based on coumarin and its derivative. The probes exhibited desirable specificity for H2Sn monitoring, which can be used for detecting H2Sn in solution and cells. The new specific recognition moiety for H2Sn fluorescent probe design discovered in this work has certain guiding significance for development of H2Sn probes exploring biological roles in the future.
WOS关键词	LIVING CELLS ; SULFIDE ; LIPOPOLYSACCHARIDE ; PERSULFIDES
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:001104798600001
资助机构	National Natural Science Foundation of China ; Major Innovation Fund of Shandong Province ; Program of Youth Innovation Promotion Association, CAS ; Taishan Scholar Project Special Funding
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/33240]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者	Zhang, Liangwei; You, Jinmao; Chen, Lingxin
作者单位	1.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China 2.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Binzhou Med Univ, Dept Biochem & Mol Biol, Yantai 264003, Peoples R China 5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 6.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xia,Yang, Yang,Zhang, Li,et al. Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide[J]. TALANTA,2024,268:8.
APA	Zhang, Xia.,Yang, Yang.,Zhang, Li.,Liu, Shudi.,Song, Zhihua.,...&Chen, Lingxin.(2024).Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide.TALANTA,268,8.
MLA	Zhang, Xia,et al."Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide".TALANTA 268(2024):8.