Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption

doi:10.1021/acs.est.3c06910

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption
	Dong, Fengfeng 1; Pan, Yitao 1; Zhang, Jian 2; Hu, Jianglin 1; Luo, Yi 2; Tang, Jianhui 2; Dai, Jiayin 1; Sheng, Nan 1
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2023-11-06
卷号	57 期号:48 页码:19442-19452
关键词	PFECA estimated daily intake dietaryexposure cereal exposure pathway
ISSN号	0013-936X
DOI	10.1021/acs.est.3c06910
通讯作者	Sheng, Nan(shengnan@sjtu.edu.cn)
英文摘要	With the replacement of perfluorooctanoic acid (PFOA) with perfluorinated ether carboxylic acids (PFECAs), residents living near fluorochemical industrial parks (FIPs) are exposed to various novel PFECAs. Despite expectations of low accumulation, short-chain PFECAs, such as perfluoro-2-methoxyacetic acid (PFMOAA), previously displayed a considerably high body burden, although the main exposure routes and health risks remain uncertain. Here, we explored the distribution of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in diverse environmental media surrounding a FIP in Shandong Province, China. PFECAs were found at elevated concentrations in all tested matrices, including vegetables, cereals, air, and dust. Among residents, 99.3% of the Sigma(36)PFAS exposure, with a 43.9% contribution from PFECAs, was due to gastrointestinal uptake. Dermal and respiratory exposures were negligible at 0.1 and 0.6%, respectively. The estimated daily intake (EDI) of PFMOAA reached 114.0 ng/kg body weight (bw)/day, ranking first among all detected PFECAs. Cereals emerged as the dominant contributor to PFMOAA body burden, representing over 80% of the overall EDI. The median EDI of hexafluoropropylene oxide dimer acid (HFPO-DA) was 17.9 ng/kg bw/day, markedly higher than the USEPA reference doses (3.0 ng/kg bw/day). The absence of established threshold values for other PFECAs constrains a comprehensive risk assessment.
WOS关键词	POLYFLUOROALKYL SUBSTANCES PFASS ; CROP BIOACCUMULATION ; DRINKING-WATER ; LEGACY ; CHAIN ; PLANT ; IDENTIFICATION ; ALTERNATIVES ; ATMOSPHERE ; PFESAS
WOS研究方向	Engineering ; Environmental Sciences & Ecology
语种	英语
WOS记录号	WOS:001114495800001
资助机构	National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Shanghai Rising-Star Program ; Young Scholar Scientific Research Foundation of National Institute of Environmental Health, China CDC
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/33186]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者	Sheng, Nan
作者单位	1.Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, State Environm Protect Key Lab Environm Hlth Impac, Shanghai 200240, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Dong, Fengfeng,Pan, Yitao,Zhang, Jian,et al. Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2023,57(48):19442-19452.
APA	Dong, Fengfeng.,Pan, Yitao.,Zhang, Jian.,Hu, Jianglin.,Luo, Yi.,...&Sheng, Nan.(2023).Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption.ENVIRONMENTAL SCIENCE & TECHNOLOGY,57(48),19442-19452.
MLA	Dong, Fengfeng,et al."Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption".ENVIRONMENTAL SCIENCE & TECHNOLOGY 57.48(2023):19442-19452.