Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9

doi:10.1038/s41467-022-33568-3

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	Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9
	He, Yuqing 2; Yu, Yingjun 2; Wang, Xiling 2; Qin, Yumei 2; Su, Chen 2; Wang, Lei 2
刊名	NATURE COMMUNICATIONS
	2022
卷号	13 期号:1
DOI	10.1038/s41467-022-33568-3
文献子类	Article
英文摘要	Circadian pace is modulated by light intensity, known as the Aschoff's rule, with largely unrevealed mechanisms. Here we report that photoreceptor CRY2 mediates blue light input to the circadian clock by directly interacting with clock core component PRR9 in blue light dependent manner. This physical interaction dually blocks the accessibility of PRR9 protein to its co-repressor TPL/TPRs and the resulting kinase PPKs. Notably, phosphorylation of PRR9 by PPKs is critical for its DNA binding and repressive activity, hence to ensure proper circadian speed. Given the labile nature of CRY2 in strong blue light, our findings provide a mechanistic explanation for Aschoff's rule in plants, i.e., blue light triggers CRY2 turnover in proportional to its intensity, which accordingly releasing PRR9 to fine tune circadian speed. Our findings not only reveal a network mediating light input into the circadian clock, but also unmask a mechanism by which the Arabidopsis circadian clock senses light intensity.
学科主题	Multidisciplinary Sciences
电子版国际标准刊号	2041-1723
出版地	BERLIN
WOS关键词	TRANSCRIPTIONAL REPRESSION ; HYPOCOTYL ELONGATION ; ARABIDOPSIS ; CRYPTOCHROMES ; GROWTH ; CCA1 ; PHYTOCHROMES ; DEGRADATION ; PROTEINS ; TIMELESS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
语种	英语
出版者	NATURE PORTFOLIO
WOS记录号	WOS:000864193100006
资助机构	Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27030206] ; National Natural Science Foundation of China [31770287]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/28862]
专题	中科院植物分子生理学重点实验室
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	He, Yuqing,Yu, Yingjun,Wang, Xiling,et al. Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9[J]. NATURE COMMUNICATIONS,2022,13(1).
APA	He, Yuqing,Yu, Yingjun,Wang, Xiling,Qin, Yumei,Su, Chen,&Wang, Lei.(2022).Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9.NATURE COMMUNICATIONS,13(1).
MLA	He, Yuqing,et al."Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9".NATURE COMMUNICATIONS 13.1(2022).