Low-Dose Ketamine-Induced Deficits in Arbitrary Visuomotor Mapping in Monkeys

doi:10.1523/ENEURO.0015-23.2023

CORC > 自动化研究所 > 中国科学院自动化研究所 > 脑图谱与类脑智能实验室

	Low-Dose Ketamine-Induced Deficits in Arbitrary Visuomotor Mapping in Monkeys
	Zhao, Zhi-Ping 4,7; Nie, Chuang 6; Jiang, Cheng-Teng 3; Cao, Sheng-Hao 1,5; Tian, Kai-Xi 2,5; Han, Xin-Yong 5; Yu, Shan 2,5; Gu, Jian-Wen 6
刊名	ENEURO
	2023-06-01
卷号	10 期号:6 页码:13
关键词	abstract rule acute cognition ketamine low-dose visuomotor mapping
DOI	10.1523/ENEURO.0015-23.2023
通讯作者	Yu, Shan(shan.yu@nlpr.ia.ac.cn) ; Gu, Jian-Wen(jiuwufushou@qq.com)
英文摘要	Ketamine, an NMDA antagonist, is widely used in clinical settings. Recently, low-dose ketamine has gained attention because of its promising role as a rapid antidepressant. However, the effects of low-dose ketamine on brain function, particularly higher cognitive functions of primate brains, are not fully understood. In this study, we used two macaques as subjects and found that acute low-dose ketamine administration significantly impaired the ability for arbitrary visuomotor mapping (AVM), a form of associative learning (AL) essential for flexible behaviors, including executions of learned stimuli-response contingency or learning of new contingencies. We conducted in-depth analyses and identified intrinsic characteristics of these ketamine-induced functional deficits, including lowered accuracy, prolonged time for planning and movement execution, increased tendency to make errors when visual cues are changed from trial to trial, and stronger impact on combining associative learning and another key higher cognitive function, working memory (WM). Our results shed new light on how associative learning relies on the NMDA-mediated synaptic transmission of the brain and contribute to a better understanding of the potential acute side effects of low-dose ketamine on cognition, which can help facilitate its safe usage in medical practice.
资助项目	STI 2030-Major Projects[2021ZD0200402] ; International Partnership Program of the Chinese Academy of Sciences (CAS)[173211KYSB2020002] ; CAS Project for Young Scientists in Basic Research[YSBR-041] ; Strategic Priority Research Program of CAS[XDB32040200]
WOS关键词	WORKING-MEMORY ; PREFRONTAL CORTEX ; ANESTHETIC KETAMINE ; COGNITIVE DEFICITS ; NMDA RECEPTORS ; PERFORMANCE ; TASK ; PERSEVERATION ; IMPAIRMENTS ; ALTERS
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SOC NEUROSCIENCE
WOS记录号	WOS:001081128400004
资助机构	STI 2030-Major Projects ; International Partnership Program of the Chinese Academy of Sciences (CAS) ; CAS Project for Young Scientists in Basic Research ; Strategic Priority Research Program of CAS
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/54394]
专题	脑图谱与类脑智能实验室
通讯作者	Yu, Shan; Gu, Jian-Wen
作者单位	1.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China 4.First Hosp Jilin Univ, Dept Ophthalmol, Changchun 130021, Peoples R China 5.Chinese Acad Sci, Lab Brain Atlas & Brain Inspired Intelligence, Inst Automat, Beijing 100190, Peoples R China 6.Strateg Support Force Med Ctr, Beijing 100101, Peoples R China 7.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Zhi-Ping,Nie, Chuang,Jiang, Cheng-Teng,et al. Low-Dose Ketamine-Induced Deficits in Arbitrary Visuomotor Mapping in Monkeys[J]. ENEURO,2023,10(6):13.
APA	Zhao, Zhi-Ping.,Nie, Chuang.,Jiang, Cheng-Teng.,Cao, Sheng-Hao.,Tian, Kai-Xi.,...&Gu, Jian-Wen.(2023).Low-Dose Ketamine-Induced Deficits in Arbitrary Visuomotor Mapping in Monkeys.ENEURO,10(6),13.
MLA	Zhao, Zhi-Ping,et al."Low-Dose Ketamine-Induced Deficits in Arbitrary Visuomotor Mapping in Monkeys".ENEURO 10.6(2023):13.