Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep

doi:10.1038/s42003-023-05439-0

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	Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep
	Cao, Yutao 4,5,6; Ai, Yue 4,5,6; Zhang, Xiaosheng 3; Zhang, Jinlong 3; Long, Xianlei 2; Zhu, Yaning 4,5,6; Wang, Linli 4,5,6; Gu, Qingyi 2; Han, Hongbing 1,4,5,6
刊名	COMMUNICATIONS BIOLOGY
	2023-10-23
卷号	6 期号:1 页码:20
DOI	10.1038/s42003-023-05439-0
通讯作者	Han, Hongbing(hanhongbing@cau.edu.cn)
英文摘要	Hypertrophy and fiber transformation are two prominent features of postnatal skeletal muscle development. However, the role of epigenetic modifications is less understood. ATAC-seq, whole genome bisulfite sequencing, and RNA-seq were applied to investigate the epigenetic dynamics of muscle in Hu sheep at 3 days, 3 months, 6 months, and 12 months after birth. All 6865 differentially expressed genes were assigned into three distinct tendencies, highlighting the balanced protein synthesis, accumulated immune activities, and restrained cell division in postnatal development. We identified 3742 differentially accessible regions and 11799 differentially methylated regions that were associated with muscle-development-related pathways in certain stages, like D3-M6. Transcription factor network analysis, based on genomic loci with high chromatin accessibility and low methylation, showed that ARID5B, MYOG, and ENO1 were associated with muscle hypertrophy, while NR1D1, FADS1, ZFP36L2, and SLC25A1 were associated with muscle fiber transformation. Taken together, these results suggest that DNA methylation and chromatin accessibility contributed toward regulating the growth and fiber transformation of postnatal skeletal muscle in Hu sheep. Multi-omic profiling of postnatal muscle development in Hu sheep from 3 days to 12 months of age highlights the epigenetic factors involved in regulating skeletal muscle growth.
资助项目	This work was supported by the National Key Ramp;D Program of China (2021YFD1300901) and the National Science Foundation of China (32172683).[2021YFD1300901] ; National Key Ramp;D Program of China[32172683] ; National Science Foundation of China
WOS关键词	MYOGENIC REGULATORY FACTORS ; SATELLITE CELLS ; TRANSCRIPTION FACTORS ; METHYLATION ; PACKAGE ; BIOGENESIS ; ALIGNMENT ; ENOLASE ; ALPHA ; MYOD
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
语种	英语
出版者	NATURE PORTFOLIO
WOS记录号	WOS:001095842600002
资助机构	This work was supported by the National Key Ramp;D Program of China (2021YFD1300901) and the National Science Foundation of China (32172683). ; National Key Ramp;D Program of China ; National Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/54397]
专题	精密感知与控制研究中心_精密感知与控制
通讯作者	Han, Hongbing
作者单位	1.China Agr Univ, Frontiers Sci Ctr Mol Design Breeding MOE, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 3.Tianjin Key Lab Anim Mol Breeding & Biotechnol, Tianjin, Peoples R China 4.China Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod, Minist Agr & Rural Affairs, Beijing, Peoples R China 5.China Agr Univ, Coll Anim Sci & Technol, Natl Engn Lab Anim Breeding, Beijing, Peoples R China 6.China Agr Univ, Coll Anim Sci & Technol, Beijing Key Lab Anim Genet Improvement, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Cao, Yutao,Ai, Yue,Zhang, Xiaosheng,et al. Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep[J]. COMMUNICATIONS BIOLOGY,2023,6(1):20.
APA	Cao, Yutao.,Ai, Yue.,Zhang, Xiaosheng.,Zhang, Jinlong.,Long, Xianlei.,...&Han, Hongbing.(2023).Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep.COMMUNICATIONS BIOLOGY,6(1),20.
MLA	Cao, Yutao,et al."Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep".COMMUNICATIONS BIOLOGY 6.1(2023):20.