Precise Localization and Simultaneous Bacterial Eradication of Biofilms Based on Nanocontainers with Successive Responsive Property toward pH and ATP | |
Wang, Yingwen1,2,3; Zhang, Dun1,2,3; Sun, Yan2,3; Zeng, Yan2,3; Qi, Peng1,2,3 | |
刊名 | ACS APPLIED MATERIALS & INTERFACES |
2023-02-06 | |
页码 | 12 |
关键词 | nanocontainers biofilm localization bacterial eradication amorphous calcium carbonate poly(acrylic acid) |
ISSN号 | 1944-8244 |
DOI | 10.1021/acsami.2c22682 |
通讯作者 | Zhang, Dun(zhangdun@qdio.ac.cn) ; Qi, Peng(qipeng@qdio.ac.cn) |
英文摘要 | The bacterial colonization of surfaces and subsequent biofilm formation are a great threat in medical therapy and clinical diagnosis. The complex internal structure and composition sets an enormous obstacle for the localization and removal of biofilms. In this study, we proposed a novel biofilm-targeted nanocontainer with successive responsive property toward pH and ATP for precise localization and simultaneous bacterial eradication, with an acidic and adenosine triphosphate (ATP)-rich micro environment within biofilms, formed due to the accumulation of fatty acids and ATP in the three-dimensional enclosed structure, integrated as two successive indicators to improve the precision of biofilm identification and removal. The biofilm-targeted nano container was composed of a ATP-responsive zeolitic imidazolate framework-90 (ZIF-90) core loaded with Rho 6G and doxorubicin hydrochloride (DOX) encapsulated in the pH-responsive amorphous calcium carbonate/poly(acrylic acid) (ACC/PAA) shell. In the presence of biofilms, the ACC/PAA shell and ZIF-90 core were successively degraded by the accumulated H+ and ATP within biofilms, resulting in the release of fluorescence indicators and antimicrobial agents. On the other hand, to meet the application requirements of different biofilm scenarios, the pH response ability of the nanocontainers could be adjusted by changing the metallic ions (Ni2+, Zn2+, and Cu2+) doped into the structure of the ACC/PAA shell. Owing to excellent water dispersion of the pH/ATP double-responsive ZIF-90@Zn-ACC/PAA nanocontainer, precise localization and simultaneous bacterial eradication was successfully realized via a simple spray process. The successive pH/ ATP two-step unlocking processes endowed the nanocontainers high precision for localization and simultaneous eradication of biofilms, which made the proposed nanocontainers high promising in food safety and medical treatment. |
资助项目 | National Natural Science Foundation of China[41876101] ; National Natural Science Foundation of China[41906037] ; Nantong Scientific Plan Foundation[JC2021054] ; Nantong Scientific Plan Foundation[JC2020090] |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000928380500001 |
内容类型 | 期刊论文 |
源URL | [http://ir.qdio.ac.cn/handle/337002/183473] |
专题 | 海洋研究所_海洋腐蚀与防护研究发展中心 |
通讯作者 | Zhang, Dun; Qi, Peng |
作者单位 | 1.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Marine Corros & Protect, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Environm Corros & Biofouling, Qingdao 266071, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yingwen,Zhang, Dun,Sun, Yan,et al. Precise Localization and Simultaneous Bacterial Eradication of Biofilms Based on Nanocontainers with Successive Responsive Property toward pH and ATP[J]. ACS APPLIED MATERIALS & INTERFACES,2023:12. |
APA | Wang, Yingwen,Zhang, Dun,Sun, Yan,Zeng, Yan,&Qi, Peng.(2023).Precise Localization and Simultaneous Bacterial Eradication of Biofilms Based on Nanocontainers with Successive Responsive Property toward pH and ATP.ACS APPLIED MATERIALS & INTERFACES,12. |
MLA | Wang, Yingwen,et al."Precise Localization and Simultaneous Bacterial Eradication of Biofilms Based on Nanocontainers with Successive Responsive Property toward pH and ATP".ACS APPLIED MATERIALS & INTERFACES (2023):12. |
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