Japanese Flounder pol-miR-155 Is Involved in Edwardsiella tarda Infection via ATG3

doi:10.3390/genes14050958

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	Japanese Flounder pol-miR-155 Is Involved in Edwardsiella tarda Infection via ATG3
	Zhang, Zhanwei 1,2; Guan, Xiaolu 1
刊名	GENES
	2023-04-22
卷号	14 期号:5 页码:12
关键词	MicroRNA Paralichthys olivaceus bacterial infection autophagy immune regulation
DOI	10.3390/genes14050958
通讯作者	Guan, Xiaolu(guanxiaolu@qdio.ac.cn)
英文摘要	MicroRNAs (miRNAs) are small RNA molecules that function in the post-transcriptionally regulation of the expression of diverse genes, including those involved in immune defense. Edwardsiella tarda can infect a broad range of hosts and cause severe disease in aquatic species, including Japanese flounder (Paralichthys olivaceus). In this study, we examined the regulation mechanism of a flounder miRNA, pol-miR-155, during the infection of E. tarda. Pol-miR-155 was identified to target flounder ATG3. Overexpression of pol-miR-155 or knockdown of ATG3 expression suppressed autophagy and promoted the intracellular replication of E. tarda in flounder cells. Overexpression of pol-miR-155 activated the NF-?B signaling pathway and further promoted the expression of downstream immune related genes of interleukin (IL)-6 and IL-8. These results unraveled the regulatory effect of pol-miR-155 in autophagy and in E. tarda infection.
资助项目	National Key Research and Development Program of China[2018YFD0900505] ; National Natural Science Foundation of China[31730100] ; National Natural Science Foundation of China[ZR2021QC124] ; Shandong Provincial Natural Science Foundation ; Taishan Scholar Program of Shandong Province
WOS关键词	CONJUGATION SYSTEM ; AUTOPHAGY ; PROTEINS ; MECHANISMS ; MICRORNAS ; MIRNAS
WOS研究方向	Genetics & Heredity
语种	英语
出版者	MDPI
WOS记录号	WOS:000997181500001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/183071]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Guan, Xiaolu
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhanwei,Guan, Xiaolu. Japanese Flounder pol-miR-155 Is Involved in Edwardsiella tarda Infection via ATG3[J]. GENES,2023,14(5):12.
APA	Zhang, Zhanwei,&Guan, Xiaolu.(2023).Japanese Flounder pol-miR-155 Is Involved in Edwardsiella tarda Infection via ATG3.GENES,14(5),12.
MLA	Zhang, Zhanwei,et al."Japanese Flounder pol-miR-155 Is Involved in Edwardsiella tarda Infection via ATG3".GENES 14.5(2023):12.