Innovative Eco-Friendly Microwave-Assisted Rapid Biosynthesis of Ag/AgCl-NPs Coated with Algae Bloom Extract as Multi-Functional Biomaterials with Non-Toxic Effects on Normal Human Cells
Pekkoh, Jeeraporn2,3,9; Ruangrit, Khomsan3; Kaewkod, Thida2; Tragoolpua, Yingmanee2; Hoijang, Supawitch1; Srisombat, Laongnuan1; Wichapein, Antira2,8; Pathom-aree, Wasu2,8; Kato, Yasuo5,6; Wang, Guangce4,7
刊名NANOMATERIALS
2023-07-01
卷号13期号:14页码:27
关键词anticancer antioxidant biosynthesis macroalgae microwave silver nanoparticles
DOI10.3390/nano13142141
通讯作者Srinuanpan, Sirasit(sirasit.s@cmu.ac.th)
英文摘要Harmful algal blooms impact human welfare and are a global concern. Sargassum spp., a type of algae or seaweed that can potentially bloom in certain regions of the sea around Thailand, exhibits a noteworthy electron capacity as the sole reducing and stabilizing agent, which suggests its potential for mediating nanoparticle composites. This study proposes an eco-friendly microwave-assisted biosynthesis (MAS) method to fabricate silver nanoparticles coated with Sargassum aqueous extract (Ag/AgCl-NPs-ME). Ag/AgCl-NPs-ME were successfully synthesized in 1 min using a 20 mM AgNO3 solution without additional hazardous chemicals. UV-visible spectroscopy confirmed their formation through a surface plasmon resonance band at 400-500 nm. XRD and FTIR analyses verified their crystalline nature and involvement of organic molecules. TEM and SEM characterization showed well-dispersed Ag/AgCl-NPs-ME with an average size of 36.43 nm. The EDS results confirmed the presence of metallic Ag+ and Cl- ions. Ag/AgCl-NPs-ME exhibited significant antioxidant activity against free radicals (DPPH, ABTS, and FRAP), suggesting their effectiveness. They also inhibited enzymes (tyrosinase and ACE) linked to diseases, indicating therapeutic potential. Importantly, the Ag/AgCl-NPs-ME displayed remarkable cytotoxicity against cancer cells (A375, A549, and Caco-2) while remaining non-toxic to normal cells. DNA ladder and TUNEL assays confirmed the activation of apoptosis mechanisms in cancer cells after a 48 h treatment. These findings highlight the versatile applications of Ag/AgCl-NPs-ME in food, cosmetics, pharmaceuticals, and nutraceuticals.
WOS关键词SILVER NANOPARTICLES AGNPS ; GREEN SYNTHESIS ; ANTIOXIDANT ACTIVITY ; AQUEOUS EXTRACT ; DEGRADATION ; ANTIBACTERIAL ; TOXICITY
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者MDPI
WOS记录号WOS:001036727100001
内容类型期刊论文
源URL[http://ir.qdio.ac.cn/handle/337002/182577]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Srinuanpan, Sirasit
作者单位1.Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand
2.Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50200, Thailand
3.Chiang Mai Univ, Multidisciplinary Res Inst, Chiang Mai 50200, Thailand
4.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
5.Toyama Prefectural Univ, Dept Biotechnol, Toyama 9390398, Japan
6.Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan
7.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
8.Chiang Mai Univ, Ctr Excellent Microbial Divers & Sustainable Utili, Chiang Mai 50200, Thailand
9.Chiang Mai Univ, Fac Sci, Environm Sci Res Ctr, Chiang Mai 50200, Thailand
推荐引用方式
GB/T 7714
Pekkoh, Jeeraporn,Ruangrit, Khomsan,Kaewkod, Thida,et al. Innovative Eco-Friendly Microwave-Assisted Rapid Biosynthesis of Ag/AgCl-NPs Coated with Algae Bloom Extract as Multi-Functional Biomaterials with Non-Toxic Effects on Normal Human Cells[J]. NANOMATERIALS,2023,13(14):27.
APA Pekkoh, Jeeraporn.,Ruangrit, Khomsan.,Kaewkod, Thida.,Tragoolpua, Yingmanee.,Hoijang, Supawitch.,...&Srinuanpan, Sirasit.(2023).Innovative Eco-Friendly Microwave-Assisted Rapid Biosynthesis of Ag/AgCl-NPs Coated with Algae Bloom Extract as Multi-Functional Biomaterials with Non-Toxic Effects on Normal Human Cells.NANOMATERIALS,13(14),27.
MLA Pekkoh, Jeeraporn,et al."Innovative Eco-Friendly Microwave-Assisted Rapid Biosynthesis of Ag/AgCl-NPs Coated with Algae Bloom Extract as Multi-Functional Biomaterials with Non-Toxic Effects on Normal Human Cells".NANOMATERIALS 13.14(2023):27.
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