Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing

	Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing
	Tian, Dehong; Han, Buying; Li, Xue; Liu, Dehui; Zhou, Baicheng; Zhao, Chunchuan; Zhang, Nan; Wang, Lei; Pei, Quanbang; Zhao, Kai
刊名	ANIMAL BIOSCIENCE
	2023
卷号	36 期号:7 页码:991
英文摘要	Objective: This study aimed to elucidate the underlying gene regions responsible for productive, phenotypic or adaptive traits in different ecological types of Tibetan sheep and the discovery of important genes encoding valuable traits.Methods: We used whole-genome resequencing to explore the genetic relationships, phylogenetic tree, and population genetic structure analysis. In addition, we identified 28 representative Tibetan sheep single-nucleotide polymorphisms (SNPs) and genomic selective sweep regions with different traits in Tibetan sheep by fixation index (Fst) and the nucleotide diversity (& theta;& pi;) ratio.Results: The genetic relationships analysis showed that each breed partitioned into its own clades and had close genetic relationships. We also identified many potential breed-specific selective sweep regions, including genes associated with hypoxic adaptability (MTOR, TRHDE, PDK1, PTPN9, TMTC2, SOX9, EPAS1, PDGFD, SOCS3, TGFBR3), coat color (MITF, MC1R, ERCC2, TCF25, ITCH, TYR, RALY, KIT), wool traits (COL4A2, ERC2, NOTCH2, ROCK1, FGF5, SOX9), and horn phenotypes (RXFP2). In particular, a horn related gene, RXFP2, showed the four most significantly associated SNP loci (g. 29481646 A>G, g. 29469024 T>C, g. 29462010 C>T, g. 29461968 C>T) and haplotypes.Conclusion: This finding demonstrates the potential for genetic markers in future molecular breeding programs to improve selection for horn phenotypes. The results will facilitate the understanding of the genetic basis of production and adaptive unique traits in Chinese indigenous Tibetan sheep taxa and offer a reference for the molecular breeding of Tibetan sheep.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61621]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Tian, Dehong,Han, Buying,Li, Xue,et al. Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing[J]. ANIMAL BIOSCIENCE,2023,36(7):991.
APA	Tian, Dehong.,Han, Buying.,Li, Xue.,Liu, Dehui.,Zhou, Baicheng.,...&Zhao, Kai.(2023).Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing.ANIMAL BIOSCIENCE,36(7),991.
MLA	Tian, Dehong,et al."Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing".ANIMAL BIOSCIENCE 36.7(2023):991.