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	Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242
	Wang, Ying2,3; Ying, Zhen2,3; Li, Xiao-Ming3; Yang, Sui-Qun3; Li, Hong-Lei3; Wang, Bin-Gui1,2,3; Meng, Ling-Hong2,3
刊名	JOURNAL OF ANTIBIOTICS
	2023-10-17
页码	7
ISSN号	0021-8820
DOI	10.1038/s41429-023-00664-5
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn)
英文摘要	Two new nonadride derivatives, namely, talarodrides G and H (1 and 2), and one new depsidone derivative, botryorhodine K (3), together with a known nonadride analogue (4), were characterized from the Magellan Seamount-derived fungus Talaromyces scorteus AS-242. Their structures were established by detailed interpretation of NMR spectroscopic and mass spectrometry data analysis. X-ray crystallographic analysis of compounds 1 and 3 confirmed their structures and absolute configurations, representing the first characterized crystal structure of a nonadride-type polyketide. The isolated compounds exhibited potent antimicrobial activities against the pathogenic bacterium MRSA and V. parahaemolyticus and pathogenic fungi C. gloeosporioides, F. oxysporum, and F. proliferatum, with MIC values ranging from 1 to 64 mu g ml(-1).
资助项目	National Natural Science Foundation of China[41976090] ; National Natural Science Foundation of China[42176115] ; Natural Science Foundation of Jiangsu Province[BK20201211] ; Senior User Project of RV KEXUE[KEXUE2020GZ02]
WOS研究方向	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
语种	英语
出版者	SPRINGERNATURE
WOS记录号	WOS:001090950000001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/181573]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Meng, Ling-Hong
作者单位	1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ying,Ying, Zhen,Li, Xiao-Ming,et al. Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242[J]. JOURNAL OF ANTIBIOTICS,2023:7.
APA	Wang, Ying.,Ying, Zhen.,Li, Xiao-Ming.,Yang, Sui-Qun.,Li, Hong-Lei.,...&Meng, Ling-Hong.(2023).Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242.JOURNAL OF ANTIBIOTICS,7.
MLA	Wang, Ying,et al."Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242".JOURNAL OF ANTIBIOTICS (2023):7.

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