Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder

doi:10.1016/j.ijchp.2023.100401

	Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder
	Li, Xuemei 11; Huang, Yang 10; Liu, Mengqi 10; Zhang, Manqi 8,9; Liu, Yang 10; Teng, Teng 11; Liu, Xueer 11; Yu, Ying 7; Jiang, Yuanliang 11; Ouyang, Xuan 8,9
刊名	INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
	2023-10-01
卷号	23 期号:4 页码:9
关键词	Childhood trauma Major depressive disorder Adolescent Functional neuroimaging Brain network
ISSN号	1697-2600
DOI	10.1016/j.ijchp.2023.100401
通讯作者	Long, Yicheng(yichenglong@csu.edu.cn) ; Zhou, Xinyu(zhouxinyu@cqmu.edu.cn)
英文摘要	Childhood trauma is a leading risk factor for adolescents developing major depressive disorder (MDD); however, the underlying neuroimaging mechanisms remain unclear. This study aimed to investigate the association among childhood trauma, MDD and brain dysfunctions by combining static and dynamic brain network models. We recruited 46 first-episode drug-naive adolescent MDD patients with childhood trauma (MDD-CT), 53 MDD patients without childhood trauma (MDD-nCT), and 90 healthy controls (HCs) for resting-state functional magnetic resonance imaging (fMRI) scans; all participants were aged 13-18 years. Compared to the HCs and MDD-nCT groups, the MDD-CT group exhibited significantly higher global and local efficiency in static brain networks and significantly higher temporal correlation coefficients in dynamic brain network models at the whole-brain level, and altered the local efficiency of default mode network (DMN) and temporal correlation coefficients of DMN, salience (SAN), and attention (ATN) networks at the local perspective. Correlation analysis indicated that altered brain network features and clinical symptoms, childhood trauma, and particularly emotional neglect were highly correlated in adolescents with MDD. This study may provide new evidence for the dysconnectivity hypothesis regarding the associations between childhood trauma and MDD in adolescents from the perspectives of both static and dynamic brain topology.
资助项目	STI2030-Major Projects[82271565] ; National Natural Science Foundation of China[82201692] ; National Natural Science Foundation of China[cstc2020jcyj-jqX0024] ; Chongqing Outstanding Youth Foundation ; [2022ZD0212900]
WOS关键词	TEST-RETEST RELIABILITY ; DEFAULT-MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; FMRI ; ORGANIZATION ; ARCHITECTURE ; METAANALYSIS ; ADVERSITIES ; ASSOCIATION ; RUMINATION
WOS研究方向	Psychology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:001053489700001
资助机构	STI2030-Major Projects ; National Natural Science Foundation of China ; Chongqing Outstanding Youth Foundation
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/53945]
专题	自动化研究所_脑网络组研究中心
通讯作者	Long, Yicheng; Zhou, Xinyu
作者单位	1.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, 1 Youyi Rd, Chongqing, Peoples R China 2.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, 139 Renmin Middle Rd, Changsha, Peoples R China 3.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, 139 Renmin Middle Rd, Changsha, Peoples R China 4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 7.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China 8.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Peoples R China 9.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China 10.Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China
推荐引用方式 GB/T 7714	Li, Xuemei,Huang, Yang,Liu, Mengqi,et al. Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder[J]. INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,2023,23(4):9.
APA	Li, Xuemei.,Huang, Yang.,Liu, Mengqi.,Zhang, Manqi.,Liu, Yang.,...&Zhou, Xinyu.(2023).Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder.INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,23(4),9.
MLA	Li, Xuemei,et al."Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder".INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY 23.4(2023):9.